0000000000702256

AUTHOR

Nils Brose

showing 2 related works from this author

Building Bridges through Science

2017

WOS: 000415310800007 PubMed ID: 29144972 Science is ideally suited to connect people from different cultures and thereby foster mutual understanding. To promote international life science collaboration, we have launched "The Science Bridge'' initiative. Our current project focuses on partnership between Western and Middle Eastern neuroscience communities. Medical Research Council [MC_UP_1202/5]

Historyhistory 15th centuryhistory 21st centuryhistory medievalInternational CooperationNeurophysiologyEurope; history 15th century; history 21st century; history ancient; history medieval; humans; middle east; neurosciences; international cooperation; neuroscience (all)Bridge (interpersonal)History 21st CenturyAncient03 medical and health sciencesMiddle East0302 clinical medicinehistory ancientPolitical scienceHumansThrough ScienceHistory AncientHistory 15th CenturyEurope; History 15th Century; History 21st Century; History Ancient; History Medieval; Humans; Middle East; Neurosciences; International Cooperation; Neuroscience (all)Neuroscience (all)General NeuroscienceBuilding BridgesNeurosciences21st CenturyHistory Medieval030227 psychiatry3. Good healthEurope15th CenturyGeneral partnershipEngineering ethics030217 neurology & neurosurgeryMedieval
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Autism Related Neuroligin-4 Knockout Impairs Intracortical Processing but not Sensory Inputs in Mouse Barrel Cortex

2016

Neuroligin-4 (Nlgn4) is a cell adhesion protein that regulates synapse organization and function. Mutations in human NLGN4 are among the causes of autism spectrum disorders. In mouse, Nlgn4 knockout (KO) perturbs GABAergic synaptic transmission and oscillatory activity in hippocampus, and causes social interaction deficits. The complex profile of cellular and circuit changes that are caused by Nlgn4-KO is still only partly understood. Using Nlgn4-KO mice, we found that Nlgn4-KO increases the power in the alpha frequency band of spontaneous network activity in the barrel cortex under urethane anesthesia in vivo. Nlgn4-KO did not affect single-whisker-induced local field potentials, but suppr…

0301 basic medicineCell Adhesion Molecules NeuronalCognitive NeuroscienceHippocampusNeocortexNeuroliginSensory systemIn Vitro TechniquesNeurotransmissionMice03 medical and health sciencesCellular and Molecular NeuroscienceGlutamatergic0302 clinical medicineAnimalsEvoked PotentialsSynapse organizationMice KnockoutNeuronsAfferent PathwaysNeurotransmitter AgentsChemistryBarrel cortexElectric StimulationVoltage-Sensitive Dye Imaging030104 developmental biologyAnimals NewbornVibrissaeExcitatory postsynaptic potentialNerve NetNeuroscience030217 neurology & neurosurgeryCerebral Cortex
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