Interrelation between macrorheological variables and insulin resistance in metabolic syndrome

Essential Hypertension: Elastase, Nitric Oxide Metabolites and Oxidative Status.

Polymorphonuclear leukocyte membrane fluidity and cytosolic Ca2+ content at baseline and after activation in essential hypertension

Obiective: To examine in essential hypertension (EH) the polymorphonuclear leukocyte (PMN) membrane fluidity and cytosolic Ca2+ content at baseline and after in vitro activation. Subjects and methods: In 45 hypertensive subjects (27 men and 18 women; mean age 45.8 +/- 11.3 years) we evaluated the PMN membrane fluidity, obtained by labeling PMNs with 1-[4-(trimethyImino)phenyl]-6phenyl-1,3,5-hexatriene (TMA-DPH) and considering the TMA-DPH polarization degree, inversely related to the membrane fluidity, and the PMN cytosolic Ca2+ content, obtained by marking PMNs with Fura 2-AM. These PMN parameters were examined at baseline and after in vitro activation (prolonged for 5 min) with two agents…

Acute ischemic stroke: leukocytes properties at the initial stage and after 30 days

Persistence of the altered polymorphonuclear leukocyte rheological and metabolic variables after 12 months in juvenile myocardial infarction

Pattern emoreologico in diversi gruppi di atleti sottoposti a test da sforzo cardiopolmonare.

Polymorphonuclear leukocyte: rheology, metabolism and integrin pattern in vascular atherosclerotic disease and in type 2 diabetes mellitus

Leukocytes, and in particular polymorphonuclear cells (PMN), play a role in the organ injury that characterizes the progression of vascular atherosclerotic disease (VAD) and diabetes mellitus (DM). We enrolled subjects with VAD, subjects with type 2 DM (DM2) and subjects with VAD and DM2. We evaluated the initial relative flow rate (IRFR) of PMN, using the St. George Filtrometer, the PMN membrane fluidity, labelling intact PMN cells with the fluorescent probe 1.4-(trimethylamino)-phenyl-4-phenylhexatriene (TMA-DPH), the PMN cytosolic Ca2+ content marking the cells with the fluorescent probe Fura 2-AM and the PMN integrin profile using the flow cytofluorimetry. All these evaluations were eff…

Deep venous thrombosis: polymorphonuclear leukocyte integrin profile

Polymorphonuclear membrane fluidity and Ca2+ content in atherosclerosis and diabetes

Cardiopatia ischemica cronica: pattern integrinico dei leucociti polimorfonucleati dopo attivazione in vitro e durante test ergometrico

Analysis of the correlations between oxidative stress, gelatinases and their tissue inhibitors in the human subjects with obstructive sleep apnea syndrome

Obstructive sleep apnea syndrome (OSAS) is commonly associated with endothelial dysfunction, atherosclerosis and cardiovascular disorders. On the basis of this observation, our aim was to examine the oxidative status and the matrix metalloproteases (MMP) profile in a group of subjects with OSAS. We enrolled 48 subjects with OSAS defined after a 1-night cardiorespiratory sleep study, who were subsequently subdivided in two subgroups according to the severity of OSAS (low grade = L-OSAS; high grade= H-OSAS). We measured the parameters of oxidative stress, such as lipid peroxidation, protein oxidation, total antioxidant status (TAS), nitric oxide metabolites (NOx), and the plasma concentration…

Insulin resistance and polymorphonuclear leukocyte membrane fluidity in obese subjects with and without type 2 diabetes mellitus

Polymorphonuclear leukocyte integrin profile in vascular atherosclerotic disease with and without type 2 diabetes mellitus.

Platelet and polymorphonuclear leukocyte activation markers in juvenile myocardial infarction

Monitoraggio delle determinanti emoreologiche nell’infarto miocardico giovanile

Acute myocardial infarction in young subjects: behaviour of plasma markers of platelet activation

Stress ossidativo e markers di attivazione granulocitaria nell'insufficienza renale cronica in trattamento conservativo e dialitico.

Elastasi e stress ossidativo in cardiopatici ischemici sottoposti a test ergometrico

Essential hypertension: polymorphonuclear leukocyte integrin profile

Polymorphonuclear leukocyte integrin profile in vascular atherosclerotic disease

Leukocyte-endothelial interactions could have a pathogenic role in atherogenesis. Adhesion molecules expressed by endothelial cells, such as intercellular adhesion molecule 1 (ICAM-1), interact with leukocyte integrins mediating the firm adhesion of leukocytes to endothelium which is followed by their transendothelial migration. The aim of our research was to evaluate polymorphonuclear leukocyte (PMN) integrin expression, at baseline and after activation, in a group of subjects with chronic vascular atherosclerotic disease (VAD). In 27 subjects with VAD we examined, at baseline and after in vitro activation with 4-phorbol 12-myristate 13-acetate (PMA), the PMN integrin pattern (CD11a, CD11b…

Effetti emoreologici del trattamento con iloprost in pazienti con fenomeno di Raynaud secondario a sclerodermia.

Polymorphonuclear leukocyte integrin expression in atherosclerosis and diabetes

Elastasi e parametri dello stress ossidativo nell’ipertensione arteriosa.