Onychomadesis Outbreak in Valencia, Spain Associated with Hand, Foot, and Mouth Disease Caused by Enteroviruses

This report evaluates the June 2008 onychomadesis outbreak in Valencia, Spain. The study sample consisted of 221 onychomadesis cases and 77 nonaffected individuals who lived close to those affected. We collected data on dietary variables, hygiene products, and individual pathological histories. Feces and blood specimens were collected from 44 cases and 24 controls to evaluate exposure to infectious agents. Pathological background data revealed a high frequency (61%) of hand, foot, and mouth disease among the onychomadesis cases. Coxsackievirus A10 was the most commonly detected enterovirus in both case and control groups (49%). Other enteroviruses such as coxsackieviruses A5, A6, A16, B1, a…

Protein Identification and Haplotype Description of Homozygote Mutation Causing Congenital Plasminogen Deficiency

Severe type I Plasminogen (PLG) deficiency was clinically diagnosed after hyaline-positive periodic acid Schiff material was detected in the histologic study of superior tarsal conjunctiva and vulvar pseudomembrane of the patient. Direct immunofluorescence also confirmed multiple deposits of fibrinogen in the dermis. Plasma plasminogen activity was calculated in a <5% value (reference values, 75% to 150%) and sequencing of the PLG gene evidenced the homozygous mutation in c.2377T/A (p.Tyr793Asn), confirming the molecular diagnosis of congenital deficiency of plasminogen type 1. Genotype-Phenotype correlation among family members evidenced the recessive hereditary pattern of clinical manifes…

Secondary syphilis as a single annular plaque on the penis mimicking granuloma annulare

Estudio molecular del condiloma acuminado: correlación clínica e histopatológica, genotipo del virus del papiloma humano y factores de riesgo asociados.

INTRODUCCIÓN: Los condilomas acuminados(CA) se encuentran entre las enfermedades más comunes de transmisión sexual. Aunque habitualmente se entiende que es el virus del papiloma humano (VPH) de bajo riesgo, genotipos 6 y 11 los que están asociados con el CA, sólo existen un número limitado de estudios publicados que informan de la prevalencia específica del genotipo del VPH. El objetivo de nuestro estudio fue evaluar la prevalencia de genotipos del VPH para un elevado número de casos que involucran tanto a hombres y mujeres y poder evaluar el beneficio potencial de una vacuna cuatrivalente (genotipos 6, 11, 16, y 18) contra el VPH en Valencia (España ) y analizar los factores de riesgo asoc…