0000000000704524

AUTHOR

A. Wassel

showing 2 related works from this author

Focal cortical damage parallels cognitive impairment in minimal hepatic encephalopathy

2012

Little attention has been paid to cortical integrity in patients with minimal hepatic encephalopathy (MHE), although cognitive functions affected in early stages of liver disease are mainly allocated in different neocortical structures. Here we used cortical surface-based analysis techniques to investigate if patterns of cortical thinning accompany the mildest form of HE. To aim this goal, cortical thickness obtained from high-resolution 31 magnetic resonance imaging (MRI) was measured in patients with no MHE (NMHE), MHE, and healthy controls. Further correlation analyses were performed to examine whether scores in the critical flicker frequency (CFF) test, and blood ammonia levels accounte…

Malemedicine.medical_specialtyPathologyCognitive NeuroscienceMinimal hepatic encephalopathyPrecuneusFlicker fusion thresholdNeuropsychological TestsCortical thicknessLiver diseaseInternal medicineImage Interpretation Computer-AssistedmedicineHumansHepatic encephalopathyTemporal cortexCerebral Cortexmedicine.diagnostic_testMagnetic resonance imagingCognitionMiddle Agedmedicine.diseaseEarly diagnosisMagnetic Resonance ImagingCalcarine sulcusmedicine.anatomical_structureEarly DiagnosisCognitive impairmentNeurologyHepatic cirrhosisHepatic EncephalopathyCardiologyFemalePsychologyCognition Disordershuman activities
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Patients with minimal hepatic encephalopathy show impaired mismatch negativity correlating with reduced performance in attention tests

2012

Attention deficit is an early event in the cognitive impairment of patients with minimal hepatic encephalopathy (MHE). The underlying mechanisms remain unclear. Mismatch negativity (MMN) is an auditory event-related potential that reflects an attentional trigger. Patients with schizophrenia show impaired attention and cognitive function, which are reflected in altered MMN. We hypothesized that patients with MHE, similarly to those with schizophrenia, should show MMN alterations related with attention deficits. The aims of this work were to assess whether (1) MMN is altered in cirrhotic patients with MHE, compared to those without MHE, (2) MMN changes in parallel with performance in attentio…

AdultMalemedicine.medical_specialtyPsychometricsPsychometricsMismatch negativityFlicker fusion thresholdAudiologybehavioral disciplines and activitiesmedicineHumansAttentionLongitudinal StudiesHepatic encephalopathyHepatologyReceiver operating characteristicbusiness.industryCognitionMiddle Agedmedicine.diseaseSchizophreniaCase-Control StudiesHepatic EncephalopathyStroop TestEvoked Potentials AuditoryFemalebusinesshuman activitiespsychological phenomena and processesStroop effect
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