0000000000705006
AUTHOR
Rodolfo Iuliano
The receptor protein tyrosine phosphatase PTPRJ negatively modulates the CD98hc oncoprotein in lung cancer cells.
PTPRJ, a receptor protein tyrosine phosphatase strongly downregulated in human cancer, displays tumor suppressor activity by negatively modulating several proteins involved in proliferating signals. Here, through a proteomic-based approach, we identified a list of potential PTPRJ-interacting proteins and among them we focused on CD98hc, a type II glycosylated integral membrane protein encoded by SLC3A2, corresponding to the heavy chain of a heterodimeric transmembrane amino-acid transporter, including LAT1. CD98hc is widely overexpressed in several types of cancers and contributes to the process of tumorigenesis by interfering with cell proliferation, adhesion, and migration. We first valid…
Role of PTPRJ genotype in papillary thyroid carcinoma risk
The strong genetic predisposition to papillary thyroid carcinoma (PTC) might be due to a combination of low-penetrance susceptibility variants. Thus, the research into gene variants involved in the increase of susceptibility to PTC is a relevant field of investigation. The gene coding for the receptor-type tyrosine phosphatase PTPRJ has been proposed as a cancer susceptibility gene, and its role as a tumor suppressor gene is well established in thyroid carcinogenesis. In this study, we want to ascertain the role of PTPRJ genotype in the risk for PTC. We performed a case–control study in which we determined the PTPRJ genotype for the non-synonymous Gln276Pro and Asp872Glu polymorphisms by PC…
¿Quién está buscando su mejor versión? Coaching y psicología deportiva en el proceso de terapeutización de (y desde) el golf
This article asks about the expansion of psychological, therapeutic and self-enhancement ethos through the networks and devices that configures middle and upper-middle classes, and about the ways in which this process is singled out starting from the encounter between coaching and psychology paradigms with golf fans, in contemporary Argentina. The empirical materials that support the analysis have been ethnographically produced from the interaction with golf players and coaches.