0000000000710003

AUTHOR

Samuel O. Yeboah

0000-0002-8070-7967

showing 4 related works from this author

Donellanic acids A–C: new cyclopropanic oleanane derivatives from Donella ubanguiensis (Sapotaceae)

2012

Abstract Three new cyclopropanic oleanane triterpenoids and ten known compounds were obtained from Donella ubanguiensis using chromatographic methods. The structures were established on the basis of mass spectrometric and NMR data and by comparison with values reported in the literature. The structures of the new compounds were confirmed by X-ray crystallography. A part of the isolated compounds was evaluated for cytotoxic and antimicrobial activities.

biologyStereochemistryOrganic Chemistrybiology.organism_classificationAntimicrobialBiochemistrySapotaceaeNmr dataMass spectrometricchemistry.chemical_compoundTriterpenoidchemistryDrug DiscoveryOrganic chemistryOleananeTetrahedron
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Omphalocarpoidone, a new lanostane-type furano-spiro-γ-lactone from the wood of Tridesmostemon omphalocarpoides Engl. (Sapotaceae)

2013

Abstract Phytochemical studies of the wood and the stem bark of Tridesmostemon omphalocarpoides Engl. (Sapotaceae) led to the isolation of omphalocarpoidone (1), a new lanostane-type furano-spiro-γ-lactone together with β-amyrin acetate (2), taraxerol (3), spinasterol (4), lichexanthone (5), epi-catechin (6), spinasterol 3-O-β- d -glucopyranoside (7), tormentic acid (8), and 1,2,3,4-tetrahydronorharman-1-one (9). Their structures were established on the basis of extensive NMR studies, mass spectrometry, and by comparison of the data with those previously reported in the literature. The structure of the new secondary metabolite was later confirmed by X-ray crystallography. Except for spinast…

chemistry.chemical_classificationStereochemistryTormentic acidPlant ScienceSecondary metaboliteBiologybiology.organism_classificationBiochemistryLanostaneSapotaceaeTaraxerolchemistry.chemical_compoundSpinasterolchemistryTriterpenemedicineOrganic chemistryAgronomy and Crop ScienceLactoneBiotechnologymedicine.drugPhytochemistry Letters
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Cytotoxic phytochemicals from the crude extract of Tetrapleura tetraptera fruits towards multi-factorial drug resistant cancer cells.

2020

Abstract Ethnopharmacological relevance Tetrapleura tetraptera is an African medicinal spice used in traditional medicine to treat several ailments including cancer. Aim of the study The present study was designed to evaluate the cytotoxicity of the dichloromethane-methanol (1:1) extract of the fruits of Tetrapleura tetraptera (TTF) and its constituents: (3R, 4S)-3,4-dimethyloxetan-2-one (1), luteolin (2), stigmasterol (4), 3-O-[6′-O-undecanoyl-β-D-glucopyranosyl]stigmasterol (6), olean-12-en-3-β-O-D-glucopyranoside (7), 3-O-β-D-glucopyranosyl-(1 → 6)-β-D-glucopyranosylurs-12-en-28-oic acid (8), 3-O-β-D-glucopyranosyl-(1 → 3)-β-D-glucopyranosyl-27-hydroxyolean-12-ene-28-oic acid (9), methyl…

Tetrapleura tetrapteraPhytochemicalsApoptosis03 medical and health scienceschemistry.chemical_compoundInhibitory Concentration 500302 clinical medicineBetulinic acidNeoplasmsDrug DiscoveryCytotoxic T cellHumansTetrapleuraCytotoxicity030304 developmental biologyPharmacologychemistry.chemical_classificationMembrane Potential Mitochondrial0303 health sciencesReactive oxygen speciesbiologyDose-Response Relationship DrugPlant ExtractsHep G2 Cellsbiology.organism_classificationHCT116 CellsMolecular biologyAntineoplastic Agents PhytogenicDrug Resistance MultipleMatrix MetalloproteinasesOxidative StresschemistryApoptosisDrug Resistance Neoplasm030220 oncology & carcinogenesisCaspasesFruitCancer cellReactive Oxygen SpeciesLuteolinSignal TransductionJournal of ethnopharmacology
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CCDC 942767: Experimental Crystal Structure Determination

2014

Related Article: Chi G. Fru, Louis P. Sandjo, Victor Kuete, Johannes C. Liermann, Dieter Schollmeyer, Samuel O. Yeboah, Renameditswe Mapitse, Berhanu M. Abegaz, Bonaventure T. Ngadjui, Till Opatz|2013|Phytochem.Lett.|6|676|doi:10.1016/j.phytol.2013.08.017

Space GroupCrystallographyCrystal SystemCrystal StructureCell Parameters(21S23R)-326-dioxo-2123:2326-diepoxylanosta-824-dien-21-ylacetateExperimental 3D Coordinates
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