Author: Pik-eu Jason Chang

0000000000711303

AUTHOR

Pik-eu Jason Chang

showing 1 related works from this author

qFIBS: A Novel Automated Technique for Quantitative Evaluation of Fibrosis, Inflammation, Ballooning, and Steatosis in Patients With Nonalcoholic Ste…

2020

[Background and Aims] Nonalcoholic steatohepatitis (NASH) is a common cause of chronic liver disease. Clinical trials use the NASH Clinical Research Network (CRN) system for semiquantitative histological assessment of disease severity. Interobserver variability may hamper histological assessment, and diagnostic consensus is not always achieved. We evaluate a second harmonic generation/two‐photon excitation fluorescence (SHG/TPEF) imaging‐based tool to provide an automated quantitative assessment of histological features pertinent to NASH.

Liver CirrhosisMale0301 basic medicineBiopsyChronic liver diseaseSeverity of Illness IndexGastroenterologyHepatitis0302 clinical medicineNon-alcoholic Fatty Liver DiseaseFibrosisNonalcoholic fatty liver diseaseqFibrosisNASH; automated; qFIBS; qFibrosis; quantitative evaluationNASH FIBROSISmedicine.diagnostic_testNASHMiddle AgedReference Standards3. Good healthLiverDimensional Measurement AccuracyLiver biopsyFemale030211 gastroenterology & hepatologyAlgorithmsmedicine.medical_specialtydigestive systemWhite People03 medical and health sciencesAsian PeopleInternal medicineImage Interpretation Computer-AssistedSeverity of illnessmedicineHumansqFIBSHepatologyReceiver operating characteristicbusiness.industryReproducibility of Resultsmedicine.diseasequantitative evaluationdigestive system diseasesConfidence intervalFatty Liver030104 developmental biologyautomatedSteatosisbusinessHepatology

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PEPhysical Sciences and Engineering
- PE2Fundamental Constituents of Matter
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LSLife Sciences
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SHSocial Sciences and Humanities
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