qFIBS: A Novel Automated Technique for Quantitative Evaluation of Fibrosis, Inflammation, Ballooning, and Steatosis in Patients With Nonalcoholic Steatohepatitis

6533b82dfe1ef96bd1290a78

RESEARCH PRODUCT

qFIBS: A Novel Automated Technique for Quantitative Evaluation of Fibrosis, Inflammation, Ballooning, and Steatosis in Patients With Nonalcoholic Steatohepatitis

George Boon-bee Goh Pik-eu Jason Chang Dina Tiniakos Dina Tiniakos Qin Wang Lai Wei Lai Wei Chee-kiat Tan Wei-keat Wan Huiying Rao Elisabetta Bugianesi Kiat Hon Lim Salvatore Petta Quentin M. Anstee Quentin M. Anstee Wei Qiang Leow Jingmin Zhao Aileen Wee Xiaoxiao Wang Manuel Romero-gómez Feng Liu Stephen A. Harrison

subject

Liver Cirrhosis Male 0301 basic medicine Biopsy Chronic liver disease Severity of Illness Index Gastroenterology Hepatitis 0302 clinical medicine Non-alcoholic Fatty Liver Disease Fibrosis Nonalcoholic fatty liver disease qFibrosis NASH; automated; qFIBS; qFibrosis; quantitative evaluation NASH FIBROSIS medicine.diagnostic_test NASH Middle Aged Reference Standards 3. Good health Liver Dimensional Measurement Accuracy Liver biopsy Female 030211 gastroenterology & hepatology Algorithms medicine.medical_specialty digestive system White People 03 medical and health sciences Asian People Internal medicine Image Interpretation Computer-Assisted Severity of illness medicine Humans qFIBS Hepatology Receiver operating characteristic business.industry Reproducibility of Results medicine.disease quantitative evaluation digestive system diseases Confidence interval Fatty Liver 030104 developmental biology automated Steatosis business

description

[Background and Aims] Nonalcoholic steatohepatitis (NASH) is a common cause of chronic liver disease. Clinical trials use the NASH Clinical Research Network (CRN) system for semiquantitative histological assessment of disease severity. Interobserver variability may hamper histological assessment, and diagnostic consensus is not always achieved. We evaluate a second harmonic generation/two‐photon excitation fluorescence (SHG/TPEF) imaging‐based tool to provide an automated quantitative assessment of histological features pertinent to NASH.

year	journal	country	edition	language
2020-05-07	Hepatology

10.1002/hep.30986 http://dx.doi.org/10.1002/hep.30986

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