0000000000711310

AUTHOR

Jingmin Zhao

showing 2 related works from this author

qFIBS: A Novel Automated Technique for Quantitative Evaluation of Fibrosis, Inflammation, Ballooning, and Steatosis in Patients With Nonalcoholic Ste…

2020

[Background and Aims] Nonalcoholic steatohepatitis (NASH) is a common cause of chronic liver disease. Clinical trials use the NASH Clinical Research Network (CRN) system for semiquantitative histological assessment of disease severity. Interobserver variability may hamper histological assessment, and diagnostic consensus is not always achieved. We evaluate a second harmonic generation/two‐photon excitation fluorescence (SHG/TPEF) imaging‐based tool to provide an automated quantitative assessment of histological features pertinent to NASH.

Liver CirrhosisMale0301 basic medicineBiopsyChronic liver diseaseSeverity of Illness IndexGastroenterologyHepatitis0302 clinical medicineNon-alcoholic Fatty Liver DiseaseFibrosisNonalcoholic fatty liver diseaseqFibrosisNASH; automated; qFIBS; qFibrosis; quantitative evaluationNASH FIBROSISmedicine.diagnostic_testNASHMiddle AgedReference Standards3. Good healthLiverDimensional Measurement AccuracyLiver biopsyFemale030211 gastroenterology & hepatologyAlgorithmsmedicine.medical_specialtydigestive systemWhite People03 medical and health sciencesAsian PeopleInternal medicineImage Interpretation Computer-AssistedSeverity of illnessmedicineHumansqFIBSHepatologyReceiver operating characteristicbusiness.industryReproducibility of Resultsmedicine.diseasequantitative evaluationdigestive system diseasesConfidence intervalFatty Liver030104 developmental biologyautomatedSteatosisbusinessHepatology
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Transient elastography compared to serum markers to predict liver fibrosis in a cohort of Chinese patients with chronic hepatitis B.

2015

Liver stiffness measurement (LSM) using transient elastography (FibroScan) is a useful tool to assess fibrosis in various chronic liver diseases. However, studies were mainly performed in Western countries and largely focused on chronic hepatitis C (CHC). We therefore carried out a multicenter study to validate the accuracy of LSM in the assessment of liver fibrosis in a large cohort of Chinese patients with chronic hepatitis B (CHB).We compared LSM results to histological staging and serum fibrosis markers (five direct markers, APRI and FIB-4) using Spearman correlation analysis and area under receiver operating characteristic (ROC) curves (AUROCs).Four hundred sixty-nine patients were enr…

AdultLiver CirrhosisMalemedicine.medical_specialtyPathologyChinaLiver fibrosisGastroenterologyCohort StudiesYoung AdultChronic hepatitisFibrosisPredictive Value of TestsInternal medicinemedicineHumansHyaluronic AcidHepatologyReceiver operating characteristicbusiness.industryGastroenterologyAlanine TransaminaseMiddle Agedmedicine.diseasePeptide FragmentsCohortBiomarker (medicine)Elasticity Imaging TechniquesFemaleLamininTransient elastographybusinessBiomarkersProcollagenSerum markersJournal of gastroenterology and hepatology
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