0000000000717595
AUTHOR
M Contoli
Innate immunity but not NLRP3 inflammasome activation correlates with severity of stable COPD.
Background In models of COPD, environmental stressors induce innate immune responses, inflammasome activation and inflammation. However, the interaction between these responses and their role in driving pulmonary inflammation in stable COPD is unknown. Objectives To investigate the activation of innate immunity and inflammasome pathways in the bronchial mucosa and bronchoalveolar lavage (BAL) of patients with stable COPD of different severity and control healthy smokers and non-smokers. Methods Innate immune mediators (interleukin (IL)-6, IL-7, IL-10, IL-27, IL-37, thymic stromal lymphopoietin (TSLP), interferon γ and their receptors, STAT1 and pSTAT1) and inflammasome components (NLRP3, NA…
Corrigendum to “Healthcare costs of the SATisfaction and adherence to COPD treatment (SAT) study follow-up” (Respiratory Medicine (2019) 153 (68–75), (S0954611119301763), (10.1016/j.rmed.2019.05.017))
The authors regret that the affiliations of two authors were incorrectly reported. The right affiliation of Fabiano di Marco is: “Department of Health Science, University of Milan, Respiratory Unit, Pope John XXIII Hospital, Bergamo, Italy”; the right affiliation of Pierachille Santus is: “Department of Biomedical and Clinical Sciences (DIBIC), University of Milan, Milan, Italy”. The authors would like to apologise for any inconvenience caused.
Th17-related cytokine expression is increased in the bronchial mucosa of stable COPD patients
Background: There is an increased number of activated Tl lymphocytes in the bronchial mucosa of stable COPD patients but are absent studies on Th17 cells and their effector cytokines.Objectives: To investigate the expression of retinoic orphan receptor(ROR)C2, interleukin(IL)-17A,IL-17F,IL-21,IL-22 and IL-23 in bronchial biopsies from patients with stable COPD of different severity(stage 2 to 4)compared with age-matched control subject(smokers with normal lung function and lifelong non-smokers).Methods: The expression of RORC2,IL-17A,IL-17F,IL-21,IL-22 and IL-23 was measured in the bronchial mucosa using immunohistochemistry and/or real time quantitative polymerase chain reaction. Results: …