0000000000718230
AUTHOR
Yasuhiro Miyake
A trigger system for measurements of proton-induced rare hadronic reactions around Tp=400MeV
Abstract We developed a trigger system for the measurement of proton-induced rare hadronic reactions around the beam kinetic energy T p = 400 MeV based on highly segmented trigger scintillation detectors and programmable logic modules. The trigger system was designed to enhance events with the negative-pion production by the difference of the curvatures of the particle tracks in a magnetic field. Since the production cross-section of the negative-pion by the proton-induced reactions was smaller by about 3 orders of magnitude than the total cross-section around the beam energy, we expected large reduction of the trigger rate by the negative-pion selection. The construction of the trigger sys…
X Chromosome Contribution to the Genetic Architecture of Primary Biliary Cholangitis
Background & aims: Genome-wide association studies in primary biliary cholangitis (PBC) have failed to find X chromosome (chrX) variants associated with the disease. Here, we specifically explore the chrX contribution to PBC, a sexually dimorphic complex autoimmune disease. Methods: We performed a chrX-wide association study, including genotype data from 5 genome-wide association studies (from Italy, United Kingdom, Canada, China, and Japan; 5244 case patients and 11,875 control individuals). Results: Single-marker association analyses found approximately 100 loci displaying P < 5 × 10-4, with the most significant being a signal within the OTUD5 gene (rs3027490; P = 4.80 × 10-6; odds…
An international genome-wide meta-analysis of primary biliary cholangitis: Novel risk loci and candidate drugs.
[BACKGROUND & AIMS] Primary biliary cholangitis (PBC) is a chronic liver disease in which autoimmune destruction of the small intra-hepatic bile ducts eventually leads to cirrhosis. Many patients have inadequate response to licensed medications, motivating the search for novel therapies. Previous genome-wide association studies (GWAS) and meta-analyses (GWMA) of PBC have identified numerous risk loci for this condition, providing insight into its aetiology. We undertook the largest GWMA of PBC to date, aiming to identify additional risk loci and prioritise candidate genes for in silico drug efficacy screening. [METHODS] We combined new and existing genotype data for 10, 516 cases and 20, 77…