showing 2 related works from this author
Dracoside, a New Steroidal Saponin fromHelleborus purpurascens
1994
Abstract A new steroidal saponin, 1-O-[6-O-acetyl-β-D-galactopyranosyl]-24-O-[β-D-apiofuranosyl-(1→3)-4-O-acetyl-α-L-rhamnopyranosyl-(1→4)-β-D-xylopyranosyl-(1→3)-α-L-arabinopyranosyl]-dracogenin, was isolated from the roots of Helleborus purpurascens and named dracoside. Structure elucidation was performed by chemical transformations and various spectroscopic methods, mainly 2D NMR techniques (COSY, HMQC, HMBC).
Resveratrol post-transcriptionally regulates pro-inflammatory gene expression via regulation of KSRP RNA binding activity
2014
Resveratrol shows beneficial effects in inflammation-based diseases like cancer, cardiovascular and chronic inflammatory diseases. Therefore, the molecular mechanisms of the anti-inflammatory resveratrol effects deserve more attention. In human epithelial DLD-1 and monocytic Mono Mac 6 cells resveratrol decreased the expression of iNOS, IL-8 and TNF-α by reducing mRNA stability without inhibition of the promoter activity. Shown by pharmacological and siRNA-mediated inhibition, the observed effects are SIRT1-independent. Target-fishing and drug responsive target stability experiments showed selective binding of resveratrol to the RNA-binding protein KSRP, a central post-transcriptional regul…