0000000000719214

AUTHOR

Simone Sforza

0000-0001-8613-3995

showing 2 related works from this author

Predicting positive surgical margins in partial nephrectomy: A prospective multicentre observational study (the RECORd 2 project)

2020

PURPOSE: to evaluate clinical predictors of positive surgical margins (PSMs) in a large multicenter prospective observational study and to develop a clinic nomogram to predict the likelihood of PSMs after partial nephrectomy (PN). MATERIALS AND METHODS: We prospectively evaluated 4308 patients who had surgical treatment for renal tumors between January 2013 and December 2016 at 26 urological Italian Centers (RECORd 2 project). Two multivariable logistic models were evaluated to predict the likelihood of PSMs. Center caseload was dichotomized using a visual assessment adjusted for several predictors of PSMs. A nomogram predicting PSMs was developed. RESULTS: Overall, 2076 patients treated wi…

MaleNeoplasm ResidualDatabases Factualmulticenter prospective observational studymedicine.medical_treatment030232 urology & nephrologyNephron-sparing surgeryNephrectomyNomogram0302 clinical medicineRenal cell carcinomaRisk Factorsclinical predictorPartial nephrectomyProspective StudiesStage (cooking)Prospective cohort studySurgical margins Nephron-sparing surgery Nomogram Partial nephrectomy Renal cell carcinoma Robot-assisted partial nephrectomySurgical marginsRobot-assisted partial nephrectomyMargins of ExcisionGeneral MedicineMiddle AgedNephrectomyKidney NeoplasmsHospitalsRenal cell carcinomaOncologyElective Surgical Procedures030220 oncology & carcinogenesisArea Under CurveResidualNephron-sparing surgery; Nomogram; Partial nephrectomy; Renal cell carcinoma; Robot-assisted partial nephrectomy; Surgical marginsFemalepositive surgical marginPositive Surgical MarginElective Surgical Proceduremedicine.medical_specialtyHospitals Low-VolumeHigh-Volume03 medical and health sciencesDatabasesSurgical margins; Nephron-sparing surgery; Nomogram; Partial nephrectomy; Renal cell carcinoma; Robot-assisted partial nephrectomyInternal medicineLow-VolumemedicineHumansNeoplasm InvasivenessCarcinoma Renal CellFactualAgedNeoplasm Stagingbusiness.industryCarcinomaRenal CellNomogrammedicine.diseaseNomogramsSettore MED/24Logistic ModelsROC CurveNeoplasmSurgeryObservational studybusinessHospitals High-Volume
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Epidermal Growth Factor Receptor (EGFR) Cell Expression During Adjuvant Treatment After Transurethral Resection for Non-Muscle-Invasive Bladder Cance…

2019

Abstract Background The aim of the study was to investigate the feasibility of Epidermal Growth Factor Receptor (EGFR) measurement in bladder washings of patients affected by non–muscle-invasive bladder cancer (NMIBC) and its prognostic role in identifying risk subgroups and predicting disease recurrence and progression. Patients and Methods Patients with NMIBC treated with transurethral resection of bladder tumor (TURBT) from 2012 to 2015 were enrolled. Samples of bladder washings were collected and stored at −80°C until RNA extraction. The cDNA obtained from RNA was used to perform a gene expression analysis by a real time polymerase chain reaction. Results An adequate cellular pellet was…

MaleOncologymedicine.medical_specialtyUrology030232 urology & nephrologyCystectomy03 medical and health sciences0302 clinical medicineInterquartile rangeInternal medicineAdjuvant therapyHumansMedicineEpidermal growth factor receptorAgedBladder cancerBladder washingbiologybusiness.industryHazard ratioCancerBiomarkerPrognosismedicine.diseaseConfidence intervalEpidermal Growth Factor Receptor (EGFR)Up-RegulationErbB ReceptorsGene Expression Regulation NeoplasticAdministration IntravesicalTreatment OutcomeUrinary Bladder NeoplasmsOncologyNon-Muscle Invasive Bladder Cancer (NMIBC)Chemotherapy Adjuvant030220 oncology & carcinogenesisMolecular classificationDisease Progressionbiology.proteinFeasibility StudiesBiomarker (medicine)Femalebusiness
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