0000000000723676
AUTHOR
M Vinciguerra
Mutual antagonism between clock protein Period2 and hepatitis C virus replication in hepatocytes.
Background: Hepatitis C virus (HCV) infects approximately 3% of the world population and is the leading cause of liver disease, impacting hepatocyte metabolism, depending on virus genotype. Hepatic metabolic functions show rhythmic fluctuations with 24-h periodicity (circadian), driven by molecular clockworks ticking through translational-transcriptional feedback loops, operated by a set of genes, called clock genes, encoding circadian proteins. Disruption of biologic clocks is implicated in a variety of disorders including fatty liver disease, obesity and diabetes. The relation between HCV replication and the circadian clock is unknown. Methods: We investigated the relationship between HCV…
I luoghi della nascita: una ricerca-intervento sui fattori di rischio nelle madri migranti
Pregnancy involves physical changes but also relational and affective ones. During the nine months’ period and in the months following the birth, women develop a series of expectations and fantasies about themselves and their child. The way women live their motherhood expresses, in addition, the cultural values, the myths, the rules society has transmitted to them. Then, birth can be considered as a cultural event with distinctive features. Moving from these considerations, we wondered how immigrant women live their experience of motherhood in a foreign country. We examined the way women reconstruct the history of their pregnancy in relation to their own maternal identity, the identity of t…