0000000000724984

AUTHOR

Imen Boumaiza

showing 2 related works from this author

Inflammation and impaired endothelium-dependant vasodilatation in non obese women with gestational diabetes mellitus: preliminary results

2013

International audience; BACKGROUND: To evaluate whether abnormal endothelial function, a common finding in gestational diabetes mellitus (GDM) pregnancies, can be explained by inflammatory cytokines. METHODS: Forearm skin blood flow (FSBF), into response to acetylcholine (Ach) (endothelium-dependent vasodilatation), were measured in 24 pregnant control subjects and 28 gestational diabetes mellitus (GDM) women, in the third trimester of gestation. A fasting glycemic and lipidic panel was obtained, and inflammatory cytokines (TNF-alpha and IL-6) and adiponectin were also determined. RESULTS: FSBF is significantly reduced in GDM group compared with control subjects (344.59 +/- 57.791 vs.176.38…

endocrine system diseases[ SDV.AEN ] Life Sciences [q-bio]/Food and NutritionEndocrinology Diabetes and MetabolismClinical BiochemistryType 2 diabetesGestational diabetes mellitusLaser Doppler flowmetry0302 clinical medicineEndocrinologyPregnancyMacrovascular diseaseMetabolic Syndrome0303 health sciences3. Good healthGestational diabetesVasodilationForearmmedicine.anatomical_structureFemaleAdiponectinAdultmedicine.medical_specialtyEndothelium030209 endocrinology & metabolism03 medical and health sciencesInternal medicinemedicineHumansObesity030304 developmental biologyGlycemicBiochemistry medicalInflammationEndothelium-Dependent Relaxing FactorsPregnancyAdiponectinbusiness.industryInterleukin-6Tumor Necrosis Factor-alphaResearchBiochemistry (medical)nutritional and metabolic diseasesmedicine.diseaseAcetylcholine[SDV.AEN] Life Sciences [q-bio]/Food and NutritionDiabetes GestationalEndocrinologyDiabetes Mellitus Type 2Regional Blood FlowEndothelium VascularMetabolic syndromebusiness[SDV.AEN]Life Sciences [q-bio]/Food and NutritionForearm skin blood flowLipids in Health and Disease
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Placental infiltration of inflammatory markers in gestational diabetic women.

2013

Gestational diabetes mellitus (GDM) is pathology of glucose intolerance during pregnancy. It is influenced by maternal hyperglycemia and insulinemia through placental circulation. The study was undertaken to investigate the implication of pro-inflammatory factors in the placenta of GDM women. Thirty GDM women have delivered macrosomic babies, and 30 healthy age-matched pregnant women have delivered non macrosomic babies, were recruited in the study. The mRNAs encoding for IL-6, TLR4, TGF-β, CD68, CD14, EMR-1, CCL2, TCR-α, T-bet, GATA-3, leptin and adiponectin were quantified in placental samples by using RT-qPCR. The mRNA expression of the pro-inflammatory factors, i.e., IL-6, TLR4 and TGF-…

AdultBlood Glucosemedicine.medical_specialtyendocrine system diseasesAdolescentPhysiologyPlacentaBiophysicsBiologyYoung AdultPregnancyInternal medicinePlacentaDiabetes mellitusmedicineHumansInsulinRNA Messengerreproductive and urinary physiologyGlycated HemoglobinInflammationPregnancyAdiponectinPlacental CirculationLeptinnutritional and metabolic diseasesGeneral Medicinemedicine.diseasefemale genital diseases and pregnancy complicationsGestational diabetesDiabetes GestationalEndocrinologymedicine.anatomical_structureGene Expression Regulationembryonic structuresGestationFemaleBiomarkersGeneral physiology and biophysics
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