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RESEARCH PRODUCT
Inflammation and impaired endothelium-dependant vasodilatation in non obese women with gestational diabetes mellitus: preliminary results
Haythem DebbabiAli BouslemaImen BoumaizaAmel ArfaInes MrizakZouhair TabkaMariem FekihMonia ZaoualiNaim Akhtar Khansubject
endocrine system diseases[ SDV.AEN ] Life Sciences [q-bio]/Food and NutritionEndocrinology Diabetes and MetabolismClinical BiochemistryType 2 diabetesGestational diabetes mellitusLaser Doppler flowmetry0302 clinical medicineEndocrinologyPregnancyMacrovascular diseaseMetabolic Syndrome0303 health sciences3. Good healthGestational diabetesVasodilationForearmmedicine.anatomical_structureFemaleAdiponectinAdultmedicine.medical_specialtyEndothelium030209 endocrinology & metabolism03 medical and health sciencesInternal medicinemedicineHumansObesity030304 developmental biologyGlycemicBiochemistry medicalInflammationEndothelium-Dependent Relaxing FactorsPregnancyAdiponectinbusiness.industryInterleukin-6Tumor Necrosis Factor-alphaResearchBiochemistry (medical)nutritional and metabolic diseasesmedicine.diseaseAcetylcholine[SDV.AEN] Life Sciences [q-bio]/Food and NutritionDiabetes GestationalEndocrinologyDiabetes Mellitus Type 2Regional Blood FlowEndothelium VascularMetabolic syndromebusiness[SDV.AEN]Life Sciences [q-bio]/Food and NutritionForearm skin blood flowdescription
International audience; BACKGROUND: To evaluate whether abnormal endothelial function, a common finding in gestational diabetes mellitus (GDM) pregnancies, can be explained by inflammatory cytokines. METHODS: Forearm skin blood flow (FSBF), into response to acetylcholine (Ach) (endothelium-dependent vasodilatation), were measured in 24 pregnant control subjects and 28 gestational diabetes mellitus (GDM) women, in the third trimester of gestation. A fasting glycemic and lipidic panel was obtained, and inflammatory cytokines (TNF-alpha and IL-6) and adiponectin were also determined. RESULTS: FSBF is significantly reduced in GDM group compared with control subjects (344.59 +/- 57.791 vs.176.38 +/- 108.52, P < 0.05). Among all subjects, FSBF showed a strong negative correlation with TNF-alpha and IL-6 (r = -0.426, P < 0.0001 and r = -0.564, P < 0.0001, respectively) and positive correlation with adiponectin (r = 0.468, P < 0.0001). CONCLUSIONS: Endothelial function, an early marker of macrovascular disease, is present in non-obese pregnancies complicated by GDM. This alteration seems to be directly related to inflammatory status, which may represent a patho-physiological link between GDM and type 2 diabetes and, later on, metabolic syndrome.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2013-06-27 | Lipids in Health and Disease |