0000000000595517

AUTHOR

Ines Mrizak

showing 4 related works from this author

The A allele of cluster of differentiation 36 (CD36) SNP 1761667 associates with decreased lipid taste perception in obese Tunisian women.

2015

Recent studies have suggested that excessive intake of dietary fat is associated with obesity. Some obese subjects have been reported to exhibit high thresholds for the gustatory detection of lipids via lipid receptors, such as cluster of differentiation 36 (CD36). We studied lingual detection thresholds for emulsions containing oleic acid in obese Tunisian women (n203) using a three-alternative forced choice (3-AFC) method. Genotyping of theTNF-α(rs1800629),IL-6(rs1800795) andCD36(rs1761667) genes was performed to associate with lipid taste perception thresholds. TheCD36genotype distribution was as follows: GG (n42), AG (n102) and AA (n59). Women with theCD36GG genotype exhibited oral dete…

AdultCD36 AntigensTastemedicine.medical_specialtyTunisiaGenotypeCD36Medicine (miscellaneous)Administration OralBiologyPolymorphism Single Nucleotidechemistry.chemical_compoundFood PreferencesInternal medicineGenotypemedicineSNPCluster AnalysisHumansObesityAllele10. No inequalityGenotypingAllelesGeneticsNutrition and DieteticsInterleukin-6Tumor Necrosis Factor-alphaTaste PerceptionMiddle Agedmedicine.diseaseTaste BudsObesityDietary FatsOleic acidEndocrinologychemistryTastebiology.proteinFemaleOleic AcidThe British journal of nutrition
researchProduct

Inflammation and impaired endothelium-dependant vasodilatation in non obese women with gestational diabetes mellitus: preliminary results

2013

International audience; BACKGROUND: To evaluate whether abnormal endothelial function, a common finding in gestational diabetes mellitus (GDM) pregnancies, can be explained by inflammatory cytokines. METHODS: Forearm skin blood flow (FSBF), into response to acetylcholine (Ach) (endothelium-dependent vasodilatation), were measured in 24 pregnant control subjects and 28 gestational diabetes mellitus (GDM) women, in the third trimester of gestation. A fasting glycemic and lipidic panel was obtained, and inflammatory cytokines (TNF-alpha and IL-6) and adiponectin were also determined. RESULTS: FSBF is significantly reduced in GDM group compared with control subjects (344.59 +/- 57.791 vs.176.38…

endocrine system diseases[ SDV.AEN ] Life Sciences [q-bio]/Food and NutritionEndocrinology Diabetes and MetabolismClinical BiochemistryType 2 diabetesGestational diabetes mellitusLaser Doppler flowmetry0302 clinical medicineEndocrinologyPregnancyMacrovascular diseaseMetabolic Syndrome0303 health sciences3. Good healthGestational diabetesVasodilationForearmmedicine.anatomical_structureFemaleAdiponectinAdultmedicine.medical_specialtyEndothelium030209 endocrinology & metabolism03 medical and health sciencesInternal medicinemedicineHumansObesity030304 developmental biologyGlycemicBiochemistry medicalInflammationEndothelium-Dependent Relaxing FactorsPregnancyAdiponectinbusiness.industryInterleukin-6Tumor Necrosis Factor-alphaResearchBiochemistry (medical)nutritional and metabolic diseasesmedicine.diseaseAcetylcholine[SDV.AEN] Life Sciences [q-bio]/Food and NutritionDiabetes GestationalEndocrinologyDiabetes Mellitus Type 2Regional Blood FlowEndothelium VascularMetabolic syndromebusiness[SDV.AEN]Life Sciences [q-bio]/Food and NutritionForearm skin blood flowLipids in Health and Disease
researchProduct

Role of T-Cell Polarization and Inflammation and Their Modulation by n-3 Fatty Acids in Gestational Diabetes and Macrosomia.

2015

Th (T helper) cells are differentiated into either Th1 or Th2 phenotype. It is generally considered that Th1 phenotype is proinflammatory, whereas Th2 phenotype exerts anti-inflammatory or protective effects. Gestational diabetes mellitus (GDM) has been associated with a decreased Th1 phenotype, whereas macrosomia is marked with high expression of Th1 cytokines. Besides, these two pathological situations are marked with high concentrations of inflammatory mediators like tumor necrosis factor-α(TNF-α) and interleukin-6 (IL-6), known to play a pivotal role in insulin resistance. Dietary n-3 polyunsaturated fatty acids (n-3 PUFAs) may exert a beneficial effect by shifting Th1/Th2 balance to a …

0301 basic medicinemedicine.medical_specialty[ SDV.AEN ] Life Sciences [q-bio]/Food and NutritionEndocrinology Diabetes and MetabolismAcyl-chainLymphocyte SubpopulationsInflammationReview ArticleBiologyProinflammatory cytokinePeripheral-Blood03 medical and health sciencesInsulin resistanceInternal medicinemedicineMultiple-sclerosislcsh:RC620-627chemistry.chemical_classificationMonocyte recruitmentNutrition and DieteticsPlasma leptinUnique populationInsulin-resistancemedicine.diseasePhenotypePathophysiologyGestational diabetesDocosahexaenoic acidlcsh:Nutritional diseases. Deficiency diseasesC-Reactive Protein030104 developmental biologyEndocrinologychemistryTumor necrosis factor alphamedicine.symptomFood SciencePolyunsaturated fatty acidJournal of nutrition and metabolism
researchProduct

Placental infiltration of inflammatory markers in gestational diabetic women.

2013

Gestational diabetes mellitus (GDM) is pathology of glucose intolerance during pregnancy. It is influenced by maternal hyperglycemia and insulinemia through placental circulation. The study was undertaken to investigate the implication of pro-inflammatory factors in the placenta of GDM women. Thirty GDM women have delivered macrosomic babies, and 30 healthy age-matched pregnant women have delivered non macrosomic babies, were recruited in the study. The mRNAs encoding for IL-6, TLR4, TGF-β, CD68, CD14, EMR-1, CCL2, TCR-α, T-bet, GATA-3, leptin and adiponectin were quantified in placental samples by using RT-qPCR. The mRNA expression of the pro-inflammatory factors, i.e., IL-6, TLR4 and TGF-…

AdultBlood Glucosemedicine.medical_specialtyendocrine system diseasesAdolescentPhysiologyPlacentaBiophysicsBiologyYoung AdultPregnancyInternal medicinePlacentaDiabetes mellitusmedicineHumansInsulinRNA Messengerreproductive and urinary physiologyGlycated HemoglobinInflammationPregnancyAdiponectinPlacental CirculationLeptinnutritional and metabolic diseasesGeneral Medicinemedicine.diseasefemale genital diseases and pregnancy complicationsGestational diabetesDiabetes GestationalEndocrinologymedicine.anatomical_structureGene Expression Regulationembryonic structuresGestationFemaleBiomarkersGeneral physiology and biophysics
researchProduct