0000000000726549
AUTHOR
V. Gerein
showing 4 related works from this author
Transient CD15-positive endothelial phenotype in the human placenta correlates with physiological and pathological fetoplacental immaturity
2013
Abstract Objective Placental growth and villous maturation are critical parameters of placental function at the end of pregnancy. A failure in these processes leads to the development of placental dysfunction, as well as fetal and neonatal mortality and morbidity. The aim of the study was to determine the relevant diagnostic markers associated with pathological placental development. Study design Forty tissue samples from normal placentas of different gestational age and 68 pathological term placentas with defective villous maturation (GDM, idiopathic IUFD, preeclamsia, HELLP syndrome) comprised the comparative immunohistochemical study (CD15, CD45 and CD34). Positive immunohistochemical re…
CD15 – A new marker of pathological villous immaturity of the term placenta
2014
Abstract Introduction Idiopathic immaturity is one of the main reasons for latent placental insufficiency and antenatal hypoxia. Postnatal identification of the immature placental phenotype may help early stratification of a heterogeneous population of newborns and individually identify risk of disease in the immediate postnatal life. The aim of the study was to determine the relevant diagnostic markers associated with pathological placental immaturity. Methods 111 tissue samples from normal and pathological term placentas with persisting villous immaturity comprised the comparative immunohistochemical study (CD15, CD34). Positive immunohistochemical reactions were quantitatively assessed i…
Imbalance of expression of bFGF and PK1 is associated with defective maturation and antenatal placental insufficiency.
2013
Abstract Objective Defective placental maturation is associated with restricted functional capacity and adverse perinatal fetal outcomes. The aim of the study was a comparative analysis of the role of mRNA expression of various angiogenic factors in placental maturation defects. Study design We examined the mRNA expression patterns of prokineticin 1 (PK1), its receptors (PKRs), basic-fibroblast growth factor (bFGF), vascular endothelial growth factor (VEGF) and placental growth factor (PlGF) in tissue from third-trimester placentae that exhibited delayed or accelerated villous maturation. Results The expression of PK1 and PKR2 was elevated in placental tissue exhibiting accelerated maturati…
Turpentine-induced fever during stimulation and inhibition of hepatic protein synthesis
2003
Abstract 1. Male Wistar rats pretreated with d -galactosamine (500 mg/kg, i.p.), a specific inhibitor of hepatic protein synthesis, developed attenuated and prolonged fever in response to turpentine (0.5 ml/rat, s.c.). 2. Hepatic protein synthesis stimulator epinephrine (1.8 mg/kg, s.c.) did not affect body temperature response of Wistar rats to turpentine. 3. Both d -galactosamine (500 mg/kg) and epinephrine (1.8 mg/kg) failed to affect body temperature in non-febrile rats. 4. These data support the hypothesis that liver-synthesised acute phase proteins might be involved in mechanisms of fever, probably, as modulators of activated cytokine network, mediating febrile response.