0000000000727101

AUTHOR

Balázs Hangya

showing 2 related works from this author

Convergence of Cortical and Sensory Driver Inputs on Single Thalamocortical Cells

2013

Ascending and descending information is relayed through the thalamus via strong, "driver" pathways. According to our current knowledge, different driver pathways are organized in parallel streams and do not interact at the thalamic level. Using an electron microscopic approach combined with optogenetics and in vivo physiology, we examined whether driver inputs arising from different sources can interact at single thalamocortical cells in the rodent somatosensory thalamus (nucleus posterior, POm). Both the anatomical and the physiological data demonstrated that ascending driver inputs from the brainstem and descending driver inputs from cortical layer 5 pyramidal neurons converge and interac…

MalePatch-Clamp TechniquesCognitive NeuroscienceThalamusBiotinMice TransgenicSensory systemOptogeneticsBiologySomatosensory systemFunctional LateralityMembrane PotentialsMiceCellular and Molecular NeuroscienceChannelrhodopsinsMicroscopy Electron TransmissionThalamusNeural PathwaysmedicineAnimalsPhytohemagglutininsRats WistarCerebral CortexNeuronsExcitatory Postsynaptic PotentialsDextransddc:Ratsmedicine.anatomical_structureCerebral cortexSynapsesRecurrent thalamo-cortical resonanceVesicular Glutamate Transport Protein 2BrainstemNucleusNeuroscienceCerebral Cortex
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OPETH: Open Source Solution for Real-Time Peri-Event Time Histogram Based on Open Ephys

2019

Single cell electrophysiology remains one of the most widely used approaches of systems neuroscience. Decisions made by the experimenter during electrophysiology recording largely determine recording quality, duration of the project and value of the collected data. Therefore, online feedback aiding these decisions can lower monetary and time investment, and substantially speed up projects as well as allow novel studies otherwise not possible due to prohibitively low throughput. Real-time feedback is especially important in studies that involve optogenetic cell type identification by enabling a systematic search for neurons of interest. However, such tools are scarce and limited to costly co…

Cell typeSpeedupComputer scienceBiomedical EngineeringNeuroscience (miscellaneous)peri-event time histogramOptogeneticsMachine learningcomputer.software_genreopen ephys050105 experimental psychologyNeuron typeslcsh:RC321-571Photostimulation03 medical and health sciencesSoftware0302 clinical medicineopen sourceHistogramMethods0501 psychology and cognitive sciencesoptogeneticslcsh:Neurosciences. Biological psychiatry. Neuropsychiatrycomputer.programming_language030304 developmental biologySystems neuroscience0303 health sciencesbusiness.industrybehavior05 social sciencesPattern recognitionPython (programming language)NeurophysiologyelectrophysiologyComputer Science ApplicationsElectrophysiologyOpen sourceCell electrophysiologyArtificial intelligencebusinesscomputer030217 neurology & neurosurgeryNeuroscienceFrontiers in Neuroinformatics
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