0000000000730285
AUTHOR
Pedro Moral Moral
Does Autoimmunity Play a Role in the Immunopathogenesis of Vasculitis Associated With Chronic Chagas Disease?
Chagas disease (CD) is a chronic systemic vector-borne infection caused by the protozoan Trypanosoma cruzi. It has spread from Latin America through migration, becoming a global issue (Perez-Molina and Molina, 2018). Its prevalence is ∼7 million people worldwide, of whom 30-40% will develop severe chronic complications such as cardiomyopathy or megaviscerae, with a considerable impact on morbimortality (WHO, 2020; WHO, 2021). The parasite is transmitted after metacyclic trypomastigotes in the feces of a triatomine insect enter the host through the bite wound. They penetrate cells and transform into amastigotes, where they multiply by binary fission and differentiate again into circulating t…
Persistent SARS-CoV-2 infection with repeated clinical recurrence in a patient with common variable immunodeficiency
This work was co-financed by the European Union through the Operational Programme of the European Regional Development Fund of Valencia Region (Spain) 2014–2020.