0000000000730835
AUTHOR
D. Amaro
XENON100 dark matter results from a combination of 477 live days
We report on WIMP search results of the XENON100 experiment, combining three runs summing up to 477 live days from January 2010 to January 2014. Data from the first two runs were already published. A blind analysis was applied to the last run recorded between April 2013 and January 2014 prior to combining the results. The ultra-low electromagnetic background of the experiment, ~$5 \times 10^{-3}$ events/(keV$_{\mathrm{ee}}\times$kg$\times$day) before electronic recoil rejection, together with the increased exposure of 48 kg $\times$ yr improves the sensitivity. A profile likelihood analysis using an energy range of (6.6 - 43.3) keV$_{\mathrm{nr}}$ sets a limit on the elastic, spin-independe…
DARWIN: Towards the ultimate dark matter detector
DARk matter WImp search with liquid xenoN (DARWIN) will be an experiment for the direct detection of dark matter using a multi-ton liquid xenon time projection chamber at its core. Its primary goal will be to explore the experimentally accessible parameter space for Weakly Interacting Massive Particles (WIMPs) in a wide mass-range, until neutrino interactions with the target become an irreducible background. The prompt scintillation light and the charge signals induced by particle interactions in the xenon will be observed by VUV sensitive, ultra-low background photosensors. Besides its excellent sensitivity to WIMPs above a mass of 5 GeV/c2, such a detector with its large mass, low-energy …
Semi-mechanistic Pharmacokinetic/Pharmacodynamic model of three pegylated rHuEPO and ior®EPOCIM in New Zealand rabbits.
Abstract Marketed formulations of erythropoietin (EPO) ior®EPOCIM, MIRCERA® and two newly developed pegylated-EPO analogues (PEG-EPO 32 and 40 kDa) formulations were intravenously administered to New Zealand rabbits. A semi-mechanistic Pharmacokinetic/Pharmacodynamic (PK/PD) model describing in a simultaneous and integrated form the time course of reticulocytes, red blood cells and hemoglobin was built to account for the time course of hematopoiesis stimulation after erythropoietin administration. Data analysis was performed based on the population approach with the software NONMEM version 7.3. Erythropoietin disposition of each of the administered formulations was best described with a two…