0000000000731082
AUTHOR
Elisabeth Larsen
A global DNA repair mechanism involving the Cockayne syndrome B (CSB) gene product can prevent the in vivo accumulation of endogenous oxidative DNA base damage
The Cockayne syndrome B (CSB) gene product is involved in the repair of various types of base modifications in actively transcribed DNA sequences. To investigate its significance for the repair of endogenous oxidative DNA damage, homozygous csb(-/-)/ogg1(-/-) double knockout mice were generated. These combine the deficiency of CSB with that of OGG1, a gene coding for the mammalian repair glycosylase that initiates the base excision repair of 7,8-dihydro-8-oxoguanine (8-oxoG). Compared to ogg1(-/-) mice, csb(-/-)/ogg1(-/-) mice were found to accumulate with age severalfold higher levels of oxidited purine modifications in hepatocytes, splenocytes and kidney cells. In contrast, the basal (ste…
Using an extended version of the theory of planned behaviour to predict smoking cessation in two age groups
The aim of this study was twofold: (i) to test the utility of the theory of planned behaviour (TPB) in predicting intentions to quit smoking and subsequent behaviour in two age groups, and among women and men, and (ii) to examine whether descriptive norms, moral norms and past behaviour predict intentions and behaviour beyond the impact of the TPB components. Analyses were based on data from a prospective sample of 447 daily smokers (adolescents 16–19 years, n = 174, M = 17.5, adults 35–55 years, n = 311, M = 44 years). The TPB accounted for 31.8% and 38% of the variance in intentions in the adolescent and adult groups, respectively. The extension variables added 12.6% and 12.1% to the …