0000000000731194

AUTHOR

Antoine Roux

showing 2 related works from this author

Enterococcus hirae and Barnesiella intestinihominis Facilitate Cyclophosphamide-Induced Therapeutic Immunomodulatory Effects.

2016

International audience; The efficacy of the anti-cancer immunomodulatory agent cyclophosphamide (CTX) relies on intestinal bacteria. How and which relevant bacterial species are involved in tumor immunosurveillance, and their mechanism of action are unclear. Here, we identified two bacterial species, Enterococcus hirae and Barnesiella intestinihominis that are involved during CTX therapy. Whereas E. hirae translocated from the small intestine to secondary lymphoid organs and increased the intratumoral CD8/ Treg ratio, B. intestinihominis accumulated in the colon and promoted the infiltration of IFN-gamma-producing gamma delta Tau cells in cancer lesions. The immune sensor, NOD2, limited CTX…

0301 basic medicineRichnessNod2 Signaling Adaptor Proteinmedicine.disease_causeMice0302 clinical medicineEnterococcus hiraeNOD2NeoplasmsIntestine Small[ SDV.IMM ] Life Sciences [q-bio]/ImmunologyImmunology and AllergyGut MicrobiotaCancerbiology3. Good healthImmunosurveillanceInfectious Diseases030220 oncology & carcinogenesisBarnesiella intestinihominis[SDV.IMM]Life Sciences [q-bio]/ImmunologyImmunotherapymedicine.symptomInfectionmedicine.drugCyclophosphamideColonImmunologyTranslocationInflammation03 medical and health sciencesInterferon-gammaImmune systemMonitoring ImmunologicmedicineAnimalsImmunologic FactorsCyclophosphamideInflammationEnterococcus hiraeAntitumor ImmunityBacteriaDendritic CellsTh1 Cellsmedicine.diseasebiology.organism_classificationMice Inbred C57BL030104 developmental biologyIntestinal MicrobiotaImmunologyOvarian cancerImmunologic MemoryImmunity
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Clinical utility of biochemical markers for the prediction of COVID-19-related mortality in kidney transplant recipients

2021

International audience

2019-20 coronavirus outbreakCoronavirus disease 2019 (COVID-19)[SDV]Life Sciences [q-bio]030232 urology & nephrologykidney transplantationInflammation030204 cardiovascular system & hematologyKidney transplantProcalcitonin03 medical and health sciences0302 clinical medicineMedicineKidney transplantationBiochemical markersComputingMilieux_MISCELLANEOUSbiologybusiness.industrytroponinbiomarkersCOVID-19medicine.diseaseTroponinResearch Letters3. Good health[SDV] Life Sciences [q-bio]NephrologyinflammationD-dimerImmunologybiology.proteinmedicine.symptombusinessprocalcitonin
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