6533b82efe1ef96bd129346b
RESEARCH PRODUCT
Enterococcus hirae and Barnesiella intestinihominis Facilitate Cyclophosphamide-Induced Therapeutic Immunomodulatory Effects.
Vichnou Poirier-colameVichnou Poirier-colameVichnou Poirier-colameSilvia C. FormentiAlexander M. M. EggermontAlexander M. M. EggermontChristophe IsnardElisabeth ChachatyDidier RaoultMaria Paula RobertiMaria Paula RobertiHarry SokolHarry SokolPatricia LepageEncouse B. GoldenDavid EnotIvo G. BonecaGuido KroemerLaurence ZitvogelNicolas JacquelotNicolas JacquelotNicolas JacquelotMutsa Tatenda MadondoMathias ChamaillardJean-charles SoriaJean-charles SoriaCaroline FlamentCaroline FlamentPhilip RosenstielMarie VétizouMarie VétizouMarie VétizouTakahiro YamazakiTakahiro YamazakiRomain DaillèreRomain DaillèreRomain DaillèreAntoine RouxSylvie RusakiewiczSylvie RusakiewiczSonia BecharefSonia BecharefVincent CattoirNadine WaldschmittBertrand RoutyBertrand RoutyBertrand RoutyPaul-louis WoertherMagdalena PlebanskiEric TartourLionel ApetohLionel ApetohPhilippe LangellaConnie P.m. DuongConnie P.m. DuongLudger JohannesLudger JohannesLudger Johannessubject
0301 basic medicineRichnessNod2 Signaling Adaptor Proteinmedicine.disease_causeMice0302 clinical medicineEnterococcus hiraeNOD2NeoplasmsIntestine Small[ SDV.IMM ] Life Sciences [q-bio]/ImmunologyImmunology and AllergyGut MicrobiotaCancerbiology3. Good healthImmunosurveillanceInfectious Diseases030220 oncology & carcinogenesisBarnesiella intestinihominis[SDV.IMM]Life Sciences [q-bio]/ImmunologyImmunotherapymedicine.symptomInfectionmedicine.drugCyclophosphamideColonImmunologyTranslocationInflammation03 medical and health sciencesInterferon-gammaImmune systemMonitoring ImmunologicmedicineAnimalsImmunologic FactorsCyclophosphamideInflammationEnterococcus hiraeAntitumor ImmunityBacteriaDendritic CellsTh1 Cellsmedicine.diseasebiology.organism_classificationMice Inbred C57BL030104 developmental biologyIntestinal MicrobiotaImmunologyOvarian cancerImmunologic Memorydescription
International audience; The efficacy of the anti-cancer immunomodulatory agent cyclophosphamide (CTX) relies on intestinal bacteria. How and which relevant bacterial species are involved in tumor immunosurveillance, and their mechanism of action are unclear. Here, we identified two bacterial species, Enterococcus hirae and Barnesiella intestinihominis that are involved during CTX therapy. Whereas E. hirae translocated from the small intestine to secondary lymphoid organs and increased the intratumoral CD8/ Treg ratio, B. intestinihominis accumulated in the colon and promoted the infiltration of IFN-gamma-producing gamma delta Tau cells in cancer lesions. The immune sensor, NOD2, limited CTX-induced cancer immunosurveillance and the bioactivity of these microbes. Finally, E. hirae and B. intestinihominis specific-memory Th1 cell immune responses selectively predicted longer progression-free survival in advanced lung and ovarian cancer patients treated with chemo-immunotherapy. Altogether, E. hirae and B. intestinihominis represent valuable ''oncomicrobiotics'' ameliorating the efficacy of the most common alkylating immunomodulatory compound.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2016-10-18 | Immunity |