Urinary collagen cross-links to evaluate hyperparathyroidism in kidney transplant patients

2008

INTRODUCTION AND AIMS: One of most common complication following kidney transplantation is reappearance of hyperparathyroidism (HP) some months after normal serum levels. An early diagnosis represents the best prophylaxis measures to prevent worsening of osteodystrophy and potential damage to the graft and vascular tissue.The aim to our study was to evaluate, beyond the common HP markers, if the urinary cross-links of the collagen PYD (pyridinoline) and DPD (Deoxypyridinoline) are useful markers able to show increasing levels of parathormone. METHODS: We evaluated 50 stable kidney transplanted patients divided into 2 group (A: 38 pts and B: 12 pts) dependent on the type of their immunosuppr…