0000000000732457
AUTHOR
M. Iorio
Methodological approach for evaluating the geo-exchange potential: VIGOR Project
In the framework of VIGOR Project, a national project coordinated by the Institute of Geosciences and Earth Resources (CNR-IGG) and sponsored by the Ministry of Economic Development (MiSE), dedicated to the evaluation of geothermal potential in the regions of the Convergence Objective in Italy (Puglia, Calabria, Campania and Sicily), is expected to evaluate the ability of the territory to heat exchange with the ground for air conditioning of buildings. To identify the conditions for the development of low enthalpy geothermal systems collected and organized on a regional scale geological and stratigraphic data useful for the preparation of a specific thematic mapping, able to represent in a …
Pleiotropic antitumor effects of the pan-HDAC inhibitor ITF2357 against c-Myc-overexpressing human B-cell non-Hodgkin lymphomas,
Histone deacetylases (HDAC) extensively contribute to the c-Myc oncogenic program, pointing to their inhibition as an effective strategy against c-Myc-overexpressing cancers. We, thus, studied the therapeutic activity of the new-generation pan-HDAC inhibitor ITF2357 (Givinostat®) against c-Myc-overexpressing human B-cell non-Hodgkin lymphomas (B-NHLs). ITF2357 anti-proliferative and pro-apoptotic effects were analyzed in B-NHL cell lines with c-Myc translocations (Namalwa, Raji and DOHH-2), stabilizing mutations (Raji) or post-transcriptional alterations (SU-DHL-4) in relationship to c-Myc modulation. ITF2357 significantly delayed the in vitro growth of all B-NHL cell lines by inducing G1 c…
Contour map of the top of the regional geothermal reservoir of Sicily (Italy).
An integrated review of existing geological and geophysical data – partly acquired during oil and gas exploration – combined with new data provided by deep geothermal studies of selected key areas, was used for the 3D modeling and mapping of the top of the geothermal reservoir developed at a regional scale in Sicily (Central Mediterranean). The resulting 1:500,000 scale map covers the area of the whole Sicily (about 25,700 km2) and is devoted to represent the main input for both the thermal modeling and the evaluation of geothermal potential at a regional scale. As the map indicates the distribution at depth of a likely target for geothermal drilling, it can be also used as a rough indicato…