0000000000736745
AUTHOR
Marco Makungu
Secoiridoids and Iridoids from Morinda asteroscepa
The new 2,3-secoiridoids morisecoiridoic acids A (1) and B (2), the new iridoid 8-acetoxyepishanzilactone (3), and four additional known iridoids (4–7) were isolated from the leaf and stem bark methanol extracts of Morinda asteroscepa using chromatographic methods. The structure of shanzilactone (4) was revised. The purified metabolites were identified using NMR spectroscopic and mass spectrometric techniques, with the absolute configuration of 1 having been established by single-crystal X-ray diffraction analysis. The crude leaf extract (10 μg/mL) and compounds 1–3 and 5 (10 μM) showed mild antiplasmodial activities against the chloroquine-sensitive malaria parasite Plasmodium falciparum (…
CCDC 1061111: Experimental Crystal Structure Determination
Related Article: Tsegaye Deyou, Marco Makungu, Matthias Heydenreich, Fangfang Pan, Amra Gruhonjic, Paul A. Fitzpatrick, Andreas Koch, Solomon Derese, Jerry Pelletier, Kari Rissanen, Abiy Yenesew, and Máté Erdélyi|2017|J.Nat.Prod.|80|2060|doi:10.1021/acs.jnatprod.7b00255
CCDC 1963302: Experimental Crystal Structure Determination
Related Article: Linda Zandi, Marco Makungu, Joan J. E. Munissi, Sandra Duffy, Rakesh Puttreddy, Daniel von der Heiden, Kari Rissanen, Vicky M. Avery, Stephen S. Nyandoro, Máté Erdélyi|2020|J.Nat.Prod.|83|2641|doi:10.1021/acs.jnatprod.0c00447