0000000000736745

AUTHOR

Marco Makungu

showing 3 related works from this author

Secoiridoids and Iridoids from Morinda asteroscepa

2020

The new 2,3-secoiridoids morisecoiridoic acids A (1) and B (2), the new iridoid 8-acetoxyepishanzilactone (3), and four additional known iridoids (4–7) were isolated from the leaf and stem bark methanol extracts of Morinda asteroscepa using chromatographic methods. The structure of shanzilactone (4) was revised. The purified metabolites were identified using NMR spectroscopic and mass spectrometric techniques, with the absolute configuration of 1 having been established by single-crystal X-ray diffraction analysis. The crude leaf extract (10 μg/mL) and compounds 1–3 and 5 (10 μM) showed mild antiplasmodial activities against the chloroquine-sensitive malaria parasite Plasmodium falciparum (…

Iridoidmedicine.drug_classMetabolitePharmaceutical Science01 natural sciencesAnalytical Chemistrychemistry.chemical_compoundDrug Discoverymedicineorgaaniset yhdisteetnuclear magnetic resonance spectroscopyPharmacologyantimikrobiset yhdisteetStem barkOrganisk kemiChromatographybiology010405 organic chemistrymatarakasvitOrganic ChemistryAbsolute configurationBiochemistry and Molecular BiologyalkylsPlasmodium falciparumbiology.organism_classificationluonnonaineetMass spectrometric0104 chemical sciences3. Good health010404 medicinal & biomolecular chemistryComplementary and alternative medicinechemistryMorindachemical structureMolecular Medicineorganic compoundsBiokemi och molekylärbiologi
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CCDC 1061111: Experimental Crystal Structure Determination

2017

Related Article: Tsegaye Deyou, Marco Makungu, Matthias Heydenreich, Fangfang Pan, Amra Gruhonjic, Paul A. Fitzpatrick, Andreas Koch, Solomon Derese, Jerry Pelletier, Kari Rissanen, Abiy Yenesew, and Máté Erdélyi|2017|J.Nat.Prod.|80|2060|doi:10.1021/acs.jnatprod.7b00255

Space GroupCrystallography(SS)-9-methoxy-6a12a-dihydrochromeno[23-c][13]dioxolo[45-g]chromen-12(6H)-oneCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 1963302: Experimental Crystal Structure Determination

2020

Related Article: Linda Zandi, Marco Makungu, Joan J. E. Munissi, Sandra Duffy, Rakesh Puttreddy, Daniel von der Heiden, Kari Rissanen, Vicky M. Avery, Stephen S. Nyandoro, Máté Erdélyi|2020|J.Nat.Prod.|83|2641|doi:10.1021/acs.jnatprod.0c00447

Space GroupCrystallographyCrystal SystemCrystal Structure24-dihydroxy-5-(3-hydroxy-1-methoxy-1-oxopropan-2-yl)-2-methylcyclopentane-1-carboxylic acidCell ParametersExperimental 3D Coordinates
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