6533b82efe1ef96bd1293ec1
RESEARCH PRODUCT
Secoiridoids and Iridoids from Morinda asteroscepa
Kari RissanenSandra DuffyMarco MakunguMarco MakunguJoan J. E. MunissiStephen S. NyandoroStephen S. NyandoroVicky M. AveryRakesh PuttreddyMáté ErdélyiMáté ErdélyiLinda ZandiDaniel Von Der Heidensubject
Iridoidmedicine.drug_classMetabolitePharmaceutical Science01 natural sciencesAnalytical Chemistrychemistry.chemical_compoundDrug Discoverymedicineorgaaniset yhdisteetnuclear magnetic resonance spectroscopyPharmacologyantimikrobiset yhdisteetStem barkOrganisk kemiChromatographybiology010405 organic chemistrymatarakasvitOrganic ChemistryAbsolute configurationBiochemistry and Molecular BiologyalkylsPlasmodium falciparumbiology.organism_classificationluonnonaineetMass spectrometric0104 chemical sciences3. Good health010404 medicinal & biomolecular chemistryComplementary and alternative medicinechemistryMorindachemical structureMolecular Medicineorganic compoundsBiokemi och molekylärbiologidescription
The new 2,3-secoiridoids morisecoiridoic acids A (1) and B (2), the new iridoid 8-acetoxyepishanzilactone (3), and four additional known iridoids (4–7) were isolated from the leaf and stem bark methanol extracts of Morinda asteroscepa using chromatographic methods. The structure of shanzilactone (4) was revised. The purified metabolites were identified using NMR spectroscopic and mass spectrometric techniques, with the absolute configuration of 1 having been established by single-crystal X-ray diffraction analysis. The crude leaf extract (10 μg/mL) and compounds 1–3 and 5 (10 μM) showed mild antiplasmodial activities against the chloroquine-sensitive malaria parasite Plasmodium falciparum (3D7). peerReviewed
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2020-08-27 |