Proceedings of the 23rd Paediatric Rheumatology European Society Congress: part one

Synthesis of hybrid anticancer agents based on kinase and histone deacetylase inhibitors

Fragments based on the VEGFR2i Semaxanib (SU5416, (vascular endothelial growth factor receptor-2\ud inhibitor) and the HDACi (histone deacetylase inhibitor) SAHA (suberanilohydroxamic acid) have been\ud merged to form a range of low molecular weight dual action hybrids. Vindication of this approach is\ud provided by SAR, docking studies, in vitro cancer cell line and biochemical enzyme inhibition data as well\ud as in vivo Xenopus data for the lead molecule (Z)-N1-(3-((1H-pyrrol-2-yl)methylene)-2-oxoindolin-5-yl)-\ud N8-hydroxyoctanediamide 6.

Reduced hadronic uncertainty in the determination of $V_{ud}$

We analyze the universal radiative correction $\Delta_R^V$ to neutron and superallowed nuclear $\beta$ decay by expressing the hadronic $\gamma W$-box contribution in terms of a dispersion relation, which we identify as an integral over the first Nachtmann moment of the $\gamma W$ interference structure function $F_3^{(0)}$. By connecting the needed input to existing data on neutrino and antineutrino scattering, we obtain an updated value of $\Delta_R^V = 0.02467(22)$, wherein the hadronic uncertainty is reduced. Assuming other Standard Model theoretical calculations and experimental measurements remain unchanged, we obtain an updated value of $|V_{ud}| = 0.97366(15)$, raising tension with …