0000000000744315

AUTHOR

Debabrata Acharya

showing 3 related works from this author

Furostane-Type Steroidal Saponins from the Roots ofChlorophytum borivilianum

2008

Four new furostanol steroid saponins, borivilianosides A–D (1–4, resp.), corresponding to (3β,5α,22R,25R)-26-(β-D-glucopyranosyloxy)-22-hydroxyfurostan-3-yl O-β-D-xylopyranosyl-(13)-O-β-D-glucopyranosyl-(14)-O-[α-L-rhamnopyranosyl-(12)]-β-D-galactopyranoside (1), (3β,5α,22R,25R)- 26-(β-D-glucopyranosyloxy)-22-methoxyfurostan-3-yl O-β-D-xylopyranosyl-(13)-O-β-D-glucopyranosyl-(14)-O-[α-L-rhamnopyranosyl-(12)]-β-D-galactopyranoside (2), (3β,5α,22R,25R)-26-(β-D-glucopyranosyloxy)-22-methoxyfurostan-3-yl O-β-D-xylopyranosyl-(13)-O-[β-D-glucopyranosyl-(12)]-O-β-D-glucopyranosyl-(14)-β-D-galactopyranoside (3), and (3β,5α,25R)-26-(β-D-glucopyranosyloxy)furost-20(22)-en-3-yl O-β-D-xylopyranosyl-(13…

biologyChemistryStereochemistryOrganic Chemistrybiology.organism_classificationBiochemistryCatalysisInorganic ChemistrySteroid SaponinsChlorophytum borivilianumDrug DiscoveryFernPhysical and Theoretical ChemistryChlorophytumHelvetica Chimica Acta
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Cytotoxic Spirostane-Type Saponins from the Roots of Chlorophytum borivilianum

2009

Four new spirostane-type saponins named borivilianosides E-H (1-4) were isolated from an ethanol extract of the roots of Chlorophytum borivilianum together with two known steroid saponins (5 and 6). The structures of 1-4 were elucidated using mainly 2D NMR spectroscopic techniques and mass spectrometry. The cytotoxicity of borivilianosides F (2), G (3), and H (4) and three known compounds was evaluated using two human colon cancer cell lines (HT-29 and HCT 116).

Chemical structureIndiaPharmaceutical SciencePharmacologyPlant RootsAnalytical ChemistrySteroid SaponinsDrug DiscoverySpirostansHumansCytotoxic T cellMedicinal plantsCytotoxicityNuclear Magnetic Resonance BiomolecularAsparagaceaePharmacologyPlants MedicinalMolecular StructurebiologyTraditional medicineChemistryOrganic ChemistrySaponinsbiology.organism_classificationAntineoplastic Agents PhytogenicHuman colon cancerComplementary and alternative medicineChlorophytum borivilianumMolecular MedicineDrug Screening Assays AntitumorTwo-dimensional nuclear magnetic resonance spectroscopyJournal of Natural Products
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Steroidal saponins from Chlorophytum orchidastrum.

2009

Six new spirostane-type saponins (1−6), named orchidastrosides A−F, and chloromaloside D were isolated from an ethanol extract of the roots of Chlorophytum orchidastrum. The saponins have neotigogenin or neogitogenin as the aglycon and oligosaccharidic chains possessing seven to nine sugar units. Their structures were elucidated mainly by 2D NMR spectroscopic analyses (COSY, TOCSY, NOESY, HSQC, and HMBC) and FABMS and HRESIMS. Compounds 1−6 were tested for cytotoxicity against two human colon cancer cell lines, HCT 116 and HT-29.

Stereochemistrymedicine.medical_treatmentChemical structureSaponinPharmaceutical SciencePharmacognosyPlant RootsAnalytical ChemistrySteroidchemistry.chemical_compoundDrug DiscoverymedicineLiliaceaeSpirostansHumansPharmacologychemistry.chemical_classificationMolecular StructureOrganic ChemistryAcetalGlycosideOligosaccharideSaponinsHCT116 CellsAntineoplastic Agents PhytogenicComplementary and alternative medicinechemistryMolecular MedicineFranceDrug Screening Assays AntitumorTwo-dimensional nuclear magnetic resonance spectroscopyHT29 CellsJournal of natural products
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