6533b859fe1ef96bd12b783d

RESEARCH PRODUCT

Cytotoxic Spirostane-Type Saponins from the Roots of Chlorophytum borivilianum

Tomofumi MiyamotoThomas PaululatAnne Claire Mitaine-offerJean François MirjoletNutan KaushikOlivier DuchampMarie Aleth Lacaille-duboisDebabrata Acharya

subject

Chemical structureIndiaPharmaceutical SciencePharmacologyPlant RootsAnalytical ChemistrySteroid SaponinsDrug DiscoverySpirostansHumansCytotoxic T cellMedicinal plantsCytotoxicityNuclear Magnetic Resonance BiomolecularAsparagaceaePharmacologyPlants MedicinalMolecular StructurebiologyTraditional medicineChemistryOrganic ChemistrySaponinsbiology.organism_classificationAntineoplastic Agents PhytogenicHuman colon cancerComplementary and alternative medicineChlorophytum borivilianumMolecular MedicineDrug Screening Assays AntitumorTwo-dimensional nuclear magnetic resonance spectroscopy

description

Four new spirostane-type saponins named borivilianosides E-H (1-4) were isolated from an ethanol extract of the roots of Chlorophytum borivilianum together with two known steroid saponins (5 and 6). The structures of 1-4 were elucidated using mainly 2D NMR spectroscopic techniques and mass spectrometry. The cytotoxicity of borivilianosides F (2), G (3), and H (4) and three known compounds was evaluated using two human colon cancer cell lines (HT-29 and HCT 116).

yearjournalcountryeditionlanguage
2009-01-07Journal of Natural Products
https://doi.org/10.1021/np800559z