0000000000745180

AUTHOR

Thomas Wilhelm-schwenkmezger

showing 3 related works from this author

Therapeutic Application of 20-kHz Transcranial Ultrasound in an Embolic Middle Cerebral Artery Occlusion Model in Rats

2007

Background and Purpose— Therapeutic application of diagnostic ultrasound has been shown to improve recanalization rates in patients with acute cerebral vessel occlusion. There is experimental evidence that low-frequency ultrasound may be superior. This study was designed to evaluate the therapeutic efficacy and safety of low-frequency ultrasound in an embolic middle cerebral artery occlusion model in rats. A parameter setting was used that had not previously shown any side effects and interactions with healthy rat brain tissue. Methods— Male Wistar rats were submitted to middle cerebral artery clot embolism and transcranial treatment with 20-kHz continuous-wave ultrasound (0.2 W/cm 2 ), ei…

MaleAdvanced and Specialized Nursingbusiness.industryUltrasonic Therapymedicine.medical_treatmentUltrasoundInfarction Middle Cerebral ArteryThrombolysismedicine.diseaseRatsTranscranial DopplerDisease Models AnimalEmbolismmedicine.arteryAnesthesiaMiddle cerebral arteryOcclusionmedicineAnimalsNeurology (clinical)Rats WistarCardiology and Cardiovascular MedicinebusinessPlasminogen activatorStrokeStroke
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Early Diagnosis of Acanthamoeba Infection during Routine Cytological Examination of Cerebrospinal Fluid

2006

ABSTRACT Early identification of Acanthamoeba in cerebrospinal fluid is mandatory to prevent fatal granulomatous amebic encephalitis. In the case presented here amebic trophozoites were detected in a routine cerebrospinal fluid sample. The antibiotic treatment and the apparently low virulence of this isolate were responsible for the benign progression of the infection.

Microbiology (medical)Pathologymedicine.medical_specialtymedicine.drug_classCerebrospinal fluid sampleMolecular Sequence DataAntibioticsVirulenceAcanthamoebaCase ReportsLoboseaCerebrospinal fluidRNA Ribosomal 18SmedicineAnimalsHumansAmebicidesCerebrospinal FluidbiologyAcanthamoeba infectionAmebiasisDNA ProtozoanMiddle Agedmedicine.diseasebiology.organism_classificationAcanthamoebaEncephalitisFemaleRNA ProtozoanEncephalitisJournal of Clinical Microbiology
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Cerebral embolic ischemia in rats: correlation of stroke severity and functional deficit as important outcome parameter.

2006

The embolic MCA occlusion model in rats is used for recanalisation studies in acute stroke. In addition to the determination of lesion size, the assessment of functional outcome may improve the value of this model. Male Wistar rats were submitted to MCA clot embolism or sham surgery. In order to achieve a larger variety of lesion volume, 2 subgroups (each 7 animals) were subjected to differently sized emboli (30 and 40 mm). Follow-up period was 6 days. Outcome assessment consisted of a test battery including parallel bar crossing, observation of behaviour in an open field and an 8-arm maze and a neurological score with ten different sensorimotor and coordinative items. Animals were perfusio…

Malemedicine.medical_specialtyIschemiaMotor ActivitySeverity of Illness IndexOpen fieldStatistics NonparametricBrain IschemiaCentral nervous system diseaseLesionDisability EvaluationInternal medicinemedicineAnimalsRats WistarMolecular BiologyStrokeAnalysis of Variancebusiness.industryVascular diseaseGeneral NeuroscienceSham surgeryBrainRecovery of Functionmedicine.diseaseSurgeryRatsStrokeDisease Models AnimalTreatment OutcomeEmbolismIntracranial EmbolismCardiologyExploratory BehaviorNeurology (clinical)medicine.symptombusinessDevelopmental BiologyBehavioral ResearchBrain research
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