0000000000745508

AUTHOR

Christian Mersch

showing 2 related works from this author

Fluorinated glycosyl amino acids for mucin-like glycopeptide antigen analogues.

2010

The aberrant glycosylation profiles of mucin glycoproteins on epithelial tumour cells represent attractive target structures for the development of immunotherapy against cancer. Mucin-type glycopeptides have been successfully investigated as molecularly defined vaccine prototypes for triggering humoral immunity but are susceptible to rapid in vivo degradation. As a potential means to enhance the bioavailabilities of the antigenic structures, hydrolysis-resistant carbohydrate analogues with fluorine substituents at positions C6, C2' and C6' were synthesised and incorporated into the tandem repeat sequence of the mucin MUC1. The resulting pseudo-glycopeptides can be used to elucidate the effe…

GlycosylationMagnetic Resonance SpectroscopyHalogenationCatalysischemistry.chemical_compoundStructure-Activity RelationshipAntigenNeoplasmsGlycosylAntigens Tumor-Associated CarbohydrateAmino Acid SequenceAmino AcidsMUC1chemistry.chemical_classificationbiologyOrganic ChemistryMucinMucin-1GlycopeptidesGeneral ChemistryGlycopeptideAmino acidchemistryBiochemistrybiology.proteinAntibodyGlycoproteinChemistry (Weinheim an der Bergstrasse, Germany)
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Antibody recognition of fluorinated MUC1 glycopeptide antigens.

2011

The syntheses of various fluorinated MUC1 glycopeptide antigens and their specific binding to serum antibodies from mice immunized with natural and fluorinated TF(6)-MUC1-TTox conjugate vaccines are presented.

digestive systemCatalysisAntibodiesAntigen-Antibody ReactionsMiceAntigenMaterials ChemistryAnimalsAntigensskin and connective tissue diseasesneoplasmsMUC1biologyChemistryMucin-1Metals and AlloysGlycopeptidesGeneral Chemistrybiological factorsdigestive system diseasesGlycopeptideSurfaces Coatings and FilmsElectronic Optical and Magnetic MaterialsBiochemistryCeramics and Compositesbiology.proteinAntibodyConjugateChemical communications (Cambridge, England)
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