0000000000745654
AUTHOR
Irēna Rinkuža
Quality of Life in Pediatric Obesity in Latvia
Abstract The aim of the retrospective case-control study was to determine if the health-related quality of life of overweight and obese children is lower than for children with optimal weight, using the KIDSCREEN-52 survey of health-related quality of life. The study examined differences in health-related quality of life assessments between children with optimal weight, and obese and over-weight children, as well as evaluated parental assessments of the quality of life of their children. In total, 200 children aged 8 to 18 years and their parents participated in the study. The results of the study showed that the total quality of life of obese (p < 0.0001) and overweight (p = 0.008) chil…
Inflammatory Cytokine IFNγ, IL-6, and IL-10 Association with Childhood Obesity
Abstract Childhood obesity carries a high risk of serious life-threatening cardiometabolic diseases in adulthood, which are associated with low-grade inflammation. The aim of the present study was to measure serum cytokine concentrations in obese children recruited during endocrinology consultations and compared to lean control the results. Blood serum concentrations of interferon gamma (IFNγ), IL-1β, Interleukin 6 IL-6, IL-10, and TNF-α were analysed applying Luminex xMap technology with Millipore reagent kits. Statistical analyses were performed using t-test comparisons and Spearman correlations. Obese children had highly significant increased levels of circulating IFNγ (p < 0.0001), I…