0000000000745685

AUTHOR

Maria Teresa Busceti

showing 2 related works from this author

Asthma management in a specialist setting: Results of an Italian Respiratory Society survey.

2017

Abstract Background Asthma considerably impairs patients' quality of life and increases healthcare costs. Severity, morbidity, and degree of disease control are the major drivers of its clinical and economic impact. National scientific societies are required to monitor the application of international guidelines and to adopt strategies to improve disease control and better allocate resources. Aim to provide a detailed picture of the characteristics of asthma patients and modalities of asthma management by specialists in Italy and to develop recommendations for the daily management of asthma in a specialist setting. Method: A quantitative research program was implemented. Data were collected…

Pulmonary and Respiratory MedicineAdultMalemedicine.medical_specialtyConcordanceSocio-culturalePractice PatternsSettore MED/10 - Malattie Dell'Apparato RespiratorioSeverity of Illness Index03 medical and health sciences0302 clinical medicineQuality of life (healthcare)Retrospective StudieSurveys and QuestionnairesSeverity of illnessHealth caremedicineSurveys and QuestionnaireHumansPharmacology (medical)030212 general & internal medicinePractice Patterns Physicians'Adult; Aged; Asthma; Female; Humans; Italy; Male; Middle Aged; Practice Patterns Physicians'; Retrospective Studies; Severity of Illness Index; Surveys and Questionnaires; Quality of Life; SpecializationAsthmaAgedRetrospective StudiesModalitiesPhysicians'business.industryBiochemistry (medical)Retrospective cohort studyMiddle Agedmedicine.diseaseAsthmaPulmonary and Respiratory Medicine; Biochemistry (medical); Pharmacology (medical)030228 respiratory systemItalyTest scoreFamily medicinePhysical therapyQuality of LifeFemalebusinessHumanSpecializationPulmonary pharmacologytherapeutics
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Benralizumab: From the Basic Mechanism of Action to the Potential Use in the Biological Therapy of Severe Eosinophilic Asthma

2018

Asthma is a very frequent chronic airway disease that includes many different clinical phenotypes and inflammatory patterns. In particular, eosinophilic bronchial inflammation is often associated with allergic as well as nonallergic asthma. The most important cytokine involved in the induction, maintenance, and amplification of airway eosinophilia in asthma is interleukin-5 (IL-5), released by both T helper 2 (Th2) lymphocytes and group 2 innate lymphoid cells (ILC2). Hence, IL-5 and its receptor are suitable targets for selective biologic drugs which can play a key role in add-on treatment of severe eosinophilic asthma refractory to corticosteroids. Within such a context, the anti-IL-5 mon…

Genetics and Molecular Biology (all)0301 basic medicineImmunology and Microbiology (all)lcsh:MedicineReview ArticleAntibodies Monoclonal HumanizedBiochemistryAntibodiesGeneral Biochemistry Genetics and Molecular Biology03 medical and health scienceschemistry.chemical_compoundTh2 Cells0302 clinical medicineReslizumabMonoclonalEosinophilicmedicineAnimalsHumansEosinophiliaHumanizedInterleukin 5AsthmaGeneral Immunology and Microbiologybusiness.industrylcsh:RInnate lymphoid cellGeneral Medicinemedicine.diseaseBenralizumabAsthmarespiratory tract diseasesBiological Therapy030104 developmental biology030228 respiratory systemchemistryImmunologyInterleukin-5medicine.symptombusinessMepolizumabAnimals; Antibodies Monoclonal Humanized; Asthma; Biological Therapy; Humans; Interleukin-5; Th2 Cells; Biochemistry Genetics and Molecular Biology (all); Immunology and Microbiology (all)medicine.drug
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