0000000000748820

AUTHOR

Massimo Maffezzini

showing 5 related works from this author

The clinical use of statistical permutation test methodology: a tool for identifying predictive variables of outcome.

2015

<b><i>Objectives:</i></b> To identify the predictive variables affecting the outcome after radical surgery for bladder cancer by a newer statistical methodology, i.e. nonparametric combination (NPC). <b><i>Methods:</i></b> A multicenter study enrolled 1,312 patients who had undergone radical cystectomy for bladder cancer in 11 Italian oncological centers from January 1982 to December 2002. A statistical analysis<b> </b>of their medical history and diagnostic, pathological and postoperative variables was performed using a NPC test. The<b> </b>patients were included in a comprehensive database with medical history and cli…

AdultMalemedicine.medical_specialtyUrologyStatistics as TopicHydronephrosisnonparametric combinationCystectomyOutcome (game theory)Statistics NonparametricBladder cancer; Permutation test; PrognosisSettore MED/24 - UrologiaBladder cancer Prognosis Permutation testPredictive Value of TestsResamplingMedicineHumansPermutation testRadical surgeryIntensive care medicineAgedNeoplasm StagingRetrospective StudiesAged 80 and overCarcinoma Transitional CellBladder cancerbusiness.industryBladder cancerProstatePermutation testsMiddle Agedmedicine.diseasePrognosisradical surgery for bladder; nonparametric combinationradical surgery for bladderSurgeryPatient Outcome Assessmentbladder cancer; Prognosis; Permutation testsItalyUrinary Bladder NeoplasmsBladdder Cancer Cystectomy outcome statistical methodologyData Interpretation StatisticalLymphatic MetastasisMultivariate AnalysisFemalePredictive variablesradical surgery for bladder nonparametric combinationbusiness
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Adherence to Guidelines among Italian Urologists on Imaging Preoperative Staging of Low-Risk Prostate Cancer: Results from the MIRROR (Multicenter It…

2011

Objective. A number of evidence-based guidelines for diagnosis and management of prostate cancer have been published. The aim of this study is to evaluate the adherence of Italian urologists to the guidelines concerning the preoperative imaging staging of prostate cancer.Methods. In October 2007 a multicentric observational perspective study called Multicentric Italian Report on Radical prostatectomy Outcome and Research (MIRROR) was started in 135 Italian urology centers. Recruitment was closed in December 2008 and 2,408 cases were collected. In this paper we have taken into consideration all examinations carried out for preoperative imaging staging, evaluating compliance with the recommen…

Gynecologymedicine.medical_specialtyArticle Subjectbusiness.industryProstatectomyUrologyGeneral surgerymedicine.medical_treatmentObstetrics and Gynecologylcsh:Diseases of the genitourinary system. Urologylcsh:RC870-923Gleason grademedicine.diseaseManagement of prostate cancerProstate cancerPreoperative stagingClinical StudyMedicineObservational studyProstatic Neoplasms Bone and Bones scan indexbusinessCost of carePreoperative imagingAdvances in urology
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The impact of prior TURP on radical prostatectomy surgical margins: A multicenter analysis and members of the mirror study, LUNA foundation

2013

Objective: To analyze positive surgical margins (PSM) after radical prostatectomy (RP) in the overall population and in patients previously treated with transurethral resection of the prostate (TURP). Materials and Methods: 2,408 patients treated with RP for clinically localized prostate cancer (PCa) were consecutively enrolled in 135 departments. We correlated PSM rates and all preoperative, surgical and pathological features. We stratified the site of PSM as unique or multifocal. Moreover, we analyzed differences between 75 patients who had undergone previous TURP and the remaining 2,333 patients. Results: In the entire study population, we identified 702 patients with PSM (29%). Using un…

AdultMaleRiskPrognosiBiopsyUrologyUrinary BladderPositive surgical marginurologic and male genital diseasesAgedAged 80 and overProstatectomyProstate cancerfungiProstateTransurethral Resection of ProstateMiddle AgedProstate-Specific AntigenRadical prostatectomyTransurethral prostate resectionPositive surgical margins; Prostate cancer; Radical prostatectomy; Transurethral prostate resection; Adult; Aged; Aged 80 and over; Biopsy; Humans; Italy; Male; Middle Aged; Neoplasm Grading; Prognosis; Prostate; Prostate-Specific Antigen; Prostatectomy; Prostatic Neoplasms; Risk; Transurethral Resection of Prostate; Treatment Outcome; Urinary Bladder; UrologyTreatment OutcomeItalyProstatic NeoplasmNeoplasm GradingHuman
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Are referral centers for non-muscle invasive bladder cancer compliant to EAU guidelines? A report from the vesical antiblastic therapy Italian study

2011

<i>Introduction:</i> Adherence to international guidelines is viewed as a prerequisite for optimal medical care delivery. Previously reported surveys for non-muscle-invasive bladder cancer (NMIBC) employed mailed questionnaires to urologists or patients resulting in conflicting degrees of agreement with existing guidelines. In the current study, contemporary information on the management of NMIBC was generated from a sample of Italian centers. <i>Patients and Methods:</i> Eight Italian referral centers for the treatment of NMIBC were asked to collect information relative to all consecutive patients with a histology-proven NMIBC undergoing a transurethral resection fr…

AdultMalemedicine.medical_specialtyReferralUrologyNon-muscle-invasive bladder cancereducationIntravesical therapyMedical careSettore MED/24 - Urologianon-muscle invasive bladder cancer; intravesical therapy; guidelines;non-muscle invasive bladder cancermedicineHumansNeoplasm InvasivenessEAU guidelinesguidelinesReferral and ConsultationAgedGynecologyAged 80 and overBladder cancerbusiness.industryGeneral surgeryBladder cancercompliant to EAU guidelinesMiddle Agedmedicine.diseaseBladder cancer; EAU guidelines; Intravesical therapy; Non-muscle-invasive bladder cancerItalyUrinary Bladder Neoplasmsnon-muscle-invasivePractice Guidelines as TopicFemaleGuideline AdherencebusinessNon muscle invasiveguideline
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The pathologist's role in the detection of rare variants of bladder cancer and analysis of the impact on incidence and type detection.

2018

BACKGROUND: Histology is one of the most important factors determining the prognosis of bladder cancers and rare variants are generally associated with decreased disease specific survival compared to pure transitional cell carcinomas. We believe that rare bladder cancer variants are likely underdiagnosed in the absence of a dedicated uro-pathologist in many centers. The objective of this study is to evaluate the contribution of a dedicated uro-pathologist on the identification of rare bladder cancer variants. METHODS: We retrospectively analyzed the clinical and histological records of all patients which underwent a radical cystectomy and lymph node dissection between January 2000 and Septe…

NephrologyMalemedicine.medical_specialtyPathologymedicine.medical_treatmentConcordanceUrology030232 urology & nephrologyCystectomyCystectomy03 medical and health sciences0302 clinical medicineProfessional RoleInternal medicineUrinary bladder neoplasmCarcinomaMedicineHumansCarcinoma transitional cell; Cystectomy; Urinary bladder neoplasms; Aged; Carcinoma Transitional Cell; Cystectomy; Female; Humans; Incidence; Lymph Node Excision; Male; Middle Aged; Professional Role; Retrospective Studies; Urinary Bladder Neoplasms; Pathologists; Nephrology; UrologyLymph nodeAgedRetrospective StudiesCarcinoma Transitional CellBladder cancerbusiness.industryIncidenceCarcinomaRetrospective cohort studyMiddle Agedmedicine.diseasePathologistsDissectionmedicine.anatomical_structureUrinary Bladder NeoplasmsNephrology030220 oncology & carcinogenesistransitional cellLymph Node ExcisionFemalebusinessMinerva urologica e nefrologica = The Italian journal of urology and nephrology
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