Magnesium in Infectious Diseases in Older People
Reduced magnesium (Mg) intake is a frequent cause of deficiency with age together with reduced absorption, renal wasting, and polypharmacotherapy. Chronic Mg deficiency may result in increased oxidative stress and low-grade inflammation, which may be linked to several age-related diseases, including higher predisposition to infectious diseases. Mg might play a role in the immune response being a cofactor for immunoglobulin synthesis and other processes strictly associated with the function of T and B cells. Mg is necessary for the biosynthesis, transport, and activation of vitamin D, another key factor in the pathogenesis of infectious diseases. The regulation of cytosolic free Mg in immune…
The relevance of magnesium homeostasis in COVID-19
Abstract Purpose In less than one and a half year, the COVID-19 pandemic has nearly brought to a collapse our health care and economic systems. The scientific research community has concentrated all possible efforts to understand the pathogenesis of this complex disease, and several groups have recently emphasized recommendations for nutritional support in COVID-19 patients. In this scoping review, we aim at encouraging a deeper appreciation of magnesium in clinical nutrition, in view of the vital role of magnesium and the numerous links between the pathophysiology of SARS-CoV-2 infection and magnesium-dependent functions. Methods By searching PubMed and Google Scholar from 1990 to date, we…
Die Bedeutung von Magnesium für Insulinresistenz, metabolisches Syndrom und Diabetes mellitus - Empfehlungen der Gesellschaft für Magnesium-Forschung e.V
Mangel an Magnesium (Mg) ist ein wichtiges und haufiges Begleitphanomen bei Patienten mit Diabetes mellitus oder Vorstufen eines Diabetes Typ 2 wie dem Metabolischen Syndrom. Mg-Mangel erhoht das Risiko, einen Diabetes Typ 2 zu entwickeln. Diese Empfehlungen resumieren die gegenwartigen Kenntnisse zur Physiologie des Mg im Kohlenhydratstoffwechsel und die pathophysiologischen Folgen des Mg-Mangels bei Diabetikern. Diabetiker und Patienten mit dessen Vorstufen profitieren von vier Kategorien der Mg-Wirkmechanismen: Insulin-sensitizing-Effekt, Ca-Antagonismus, Stress-Regulation und Endothel-stabilisierender Effekt. Klinische Studiendaten mit Mg-Comedikation zeigen verminderte Insulinresistenz…