0000000000752305

AUTHOR

Alexander Segner

showing 4 related works from this author

3 years of liraglutide versus placebo for type 2 diabetes risk reduction and weight management in individuals with prediabetes: a randomised, double-…

2017

Background: \ud Liraglutide 3·0 mg was shown to reduce bodyweight and improve glucose metabolism after the 56-week period of this trial, one of four trials in the SCALE programme. In the 3-year assessment of the SCALE Obesity and Prediabetes trial we aimed to evaluate the proportion of individuals with prediabetes who were diagnosed with type 2 diabetes.\ud \ud Methods: \ud In this randomised, double-blind, placebo-controlled trial, adults with prediabetes and a body-mass index of at least 30 kg/m2, or at least 27 kg/m2 with comorbidities, were randomised 2:1, using a telephone or web-based system, to once-daily subcutaneous liraglutide 3·0 mg or matched placebo, as an adjunct to a reduced-…

Blood GlucoseMaleEXENATIDEType 2 diabetes030204 cardiovascular system & hematologyBody Mass Indexlaw.inventionPlacebosImpaired glucose toleranceMELLITUS3.0 MG0302 clinical medicineRandomized controlled trialGlucagon-Like Peptide 1lawPREVENTION PROGRAM OUTCOMESPrediabetesPREVENTION PROGRAM OUTCOMES; IMPAIRED GLUCOSE-TOLERANCE; LIFE-STYLE; CLINICAL-TRIAL; OBESE SUBJECTS; 3.0 MG; REGRESSION; EXENATIDE; MELLITUSSubcutaneousMedicine (all)General MedicineMiddle AgedAdult; Blood Glucose; Body Mass Index; Body Weight; Diabetes Mellitus Type 2; Double-Blind Method; Female; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Humans; Hypoglycemic Agents; Incretins; Injections Subcutaneous; Liraglutide; Male; Middle Aged; Obesity; Placebos; Prediabetic State; Risk Reduction Behavior; Treatment Outcome; Weight Loss3. Good healthTreatment OutcomeFemaleLIFE-STYLEType 2OBESE SUBJECTSmedicine.drugAdultmedicine.medical_specialtyInjections Subcutaneous030209 endocrinology & metabolismPlaceboIncretinsGlucagon-Like Peptide-1 ReceptorInjectionsCLINICAL-TRIALPrediabetic State03 medical and health sciencesIMPAIRED GLUCOSE-TOLERANCEDouble-Blind MethodDiabetes mellitusInternal medicineWeight LossREGRESSIONDiabetes MellitusmedicineHumansHypoglycemic AgentsObesityLiraglutidebusiness.industryBody WeightLiraglutidemedicine.diseaseClinical trialEndocrinologyDiabetes Mellitus Type 2Human medicinebusinessRisk Reduction Behavior[SDV.AEN]Life Sciences [q-bio]/Food and Nutrition[SDV.MHEP]Life Sciences [q-bio]/Human health and pathologyThe Lancet
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Pairwise Learning to Rank by Neural Networks Revisited: Reconstruction, Theoretical Analysis and Practical Performance

2020

We present a pairwise learning to rank approach based on a neural net, called DirectRanker, that generalizes the RankNet architecture. We show mathematically that our model is reflexive, antisymmetric, and transitive allowing for simplified training and improved performance. Experimental results on the LETOR MSLR-WEB10K, MQ2007 and MQ2008 datasets show that our model outperforms numerous state-of-the-art methods, while being inherently simpler in structure and using a pairwise approach only.

Transitive relationPairwise learningTheoretical computer scienceArtificial neural networkAntisymmetric relationComputer scienceRank (computer programming)Structure (category theory)Pairwise comparisonLearning to rank
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Shining Light on the Scotogenic Model: Interplay of Colliders and Cosmology

2019

In the framework of the scotogenic model, which features radiative generation of neutrino masses, we explore light dark matter scenario. Throughout the paper we chiefly focus on keV-scale dark matter which can be produced either via freeze-in through the decays of the new scalars, or from the decays of next-to-lightest fermionic particle in the spectrum, which is produced through freeze-out. The latter mechanism is required to be suppressed as it typically produces a hot dark matter component. Constraints from BBN are also considered and in combination with the former production mechanism they impose the dark matter to be light. For this scenario we consider signatures at High Luminosity LH…

Nuclear and High Energy PhysicsParticle physicsCosmology and Nongalactic Astrophysics (astro-ph.CO)Dark matterFOS: Physical sciencesAstrophysics::Cosmology and Extragalactic Astrophysics01 natural sciencesCosmologyHigh Energy Physics - Phenomenology (hep-ph)0103 physical sciencesNeutrino Physicslcsh:Nuclear and particle physics. Atomic energy. Radioactivity010306 general physicsLight dark matterPhysicsLarge Hadron ColliderMissing energy010308 nuclear & particles physicsHot dark matterCosmology of Theories beyond the SMHigh Energy Physics - PhenomenologyBeyond Standard Modellcsh:QC770-798High Energy Physics::ExperimentNeutrinoLeptonAstrophysics - Cosmology and Nongalactic Astrophysics
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Fair Pairwise Learning to Rank

2020

Ranking algorithms based on Neural Networks have been a topic of recent research. Ranking is employed in everyday applications like product recommendations, search results, or even in finding good candidates for hiring. However, Neural Networks are mostly opaque tools, and it is hard to evaluate why a specific candidate, for instance, was not considered. Therefore, for neural-based ranking methods to be trustworthy, it is crucial to guarantee that the outcome is fair and that the decisions are not discriminating people according to sensitive attributes such as gender, sexual orientation, or ethnicity.In this work we present a family of fair pairwise learning to rank approaches based on Neur…

FairnessArtificial neural networkNeural Networksbusiness.industryComputer science05 social sciencesRank (computer programming)02 engineering and technologyMachine learningcomputer.software_genreFairness Neural Networks RankingOutcome (game theory)Ranking (information retrieval)Correlation020204 information systems0202 electrical engineering electronic engineering information engineeringRelevance (information retrieval)Learning to rankProduct (category theory)Artificial intelligenceRanking0509 other social sciences050904 information & library sciencesbusinesscomputer
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