0000000000752305
AUTHOR
Alexander Segner
3 years of liraglutide versus placebo for type 2 diabetes risk reduction and weight management in individuals with prediabetes: a randomised, double-blind trial
Background: \ud Liraglutide 3·0 mg was shown to reduce bodyweight and improve glucose metabolism after the 56-week period of this trial, one of four trials in the SCALE programme. In the 3-year assessment of the SCALE Obesity and Prediabetes trial we aimed to evaluate the proportion of individuals with prediabetes who were diagnosed with type 2 diabetes.\ud \ud Methods: \ud In this randomised, double-blind, placebo-controlled trial, adults with prediabetes and a body-mass index of at least 30 kg/m2, or at least 27 kg/m2 with comorbidities, were randomised 2:1, using a telephone or web-based system, to once-daily subcutaneous liraglutide 3·0 mg or matched placebo, as an adjunct to a reduced-…
Pairwise Learning to Rank by Neural Networks Revisited: Reconstruction, Theoretical Analysis and Practical Performance
We present a pairwise learning to rank approach based on a neural net, called DirectRanker, that generalizes the RankNet architecture. We show mathematically that our model is reflexive, antisymmetric, and transitive allowing for simplified training and improved performance. Experimental results on the LETOR MSLR-WEB10K, MQ2007 and MQ2008 datasets show that our model outperforms numerous state-of-the-art methods, while being inherently simpler in structure and using a pairwise approach only.
Shining Light on the Scotogenic Model: Interplay of Colliders and Cosmology
In the framework of the scotogenic model, which features radiative generation of neutrino masses, we explore light dark matter scenario. Throughout the paper we chiefly focus on keV-scale dark matter which can be produced either via freeze-in through the decays of the new scalars, or from the decays of next-to-lightest fermionic particle in the spectrum, which is produced through freeze-out. The latter mechanism is required to be suppressed as it typically produces a hot dark matter component. Constraints from BBN are also considered and in combination with the former production mechanism they impose the dark matter to be light. For this scenario we consider signatures at High Luminosity LH…
Fair Pairwise Learning to Rank
Ranking algorithms based on Neural Networks have been a topic of recent research. Ranking is employed in everyday applications like product recommendations, search results, or even in finding good candidates for hiring. However, Neural Networks are mostly opaque tools, and it is hard to evaluate why a specific candidate, for instance, was not considered. Therefore, for neural-based ranking methods to be trustworthy, it is crucial to guarantee that the outcome is fair and that the decisions are not discriminating people according to sensitive attributes such as gender, sexual orientation, or ethnicity.In this work we present a family of fair pairwise learning to rank approaches based on Neur…