0000000000755285

AUTHOR

Gaetano Zaccara

showing 2 related works from this author

Do neurologists agree in diagnosing drug resistance in adults with focal epilepsy?

2019

Objective: To evaluate interrater agreement in categorizing treatment outcomes and drug responsiveness status according to the International League Against Epilepsy (ILAE) definition of drug-resistant epilepsy. Methods: A total of 1053 adults with focal epilepsy considered by the investigators to meet ILAE criteria for drug resistance were enrolled consecutively at 43 centers and followed up prospectively for 18-34 months. Treatment outcomes for all antiepileptic drugs (AEDs) used up to enrollment (retrospective assessment), and on an AED newly introduced at enrollment, were categorized by individual investigators and by 2 rotating members of a 16-member expert panel (EP) that reviewed the …

AdultMale0301 basic medicineDrug Resistant Epilepsymedicine.medical_specialtyPediatricsNeurologyAttitude of Health PersonnelTreatment outcomeantiepileptic drugs; classification; drug-resistant epilepsy; epilepsy; ILAE definition; reliability; Neurology; Neurology (clinical)Drug resistance03 medical and health sciencesEpilepsyantiepileptic drug0302 clinical medicinedrug-resistant epilepsymedicineHumansNeurologistsProspective Studiesantiepileptic drugsCooperative Behaviorreliabilitybusiness.industryMiddle Agedmedicine.diseaseDrug Resistant EpilepsyConfidence intervalInter-rater reliability030104 developmental biologyclassificationNeurologyepilepsyAnticonvulsantsFemaleEpilepsies PartialNeurology (clinical)businessILAE definition030217 neurology & neurosurgeryKappa
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"…The times they aren't a-changin'…" rTMS does not affect basic mechanisms of temporal discrimination: a pilot study with ERPs.

2014

In time processing, the role of different cortical areas is still under investigation. Event-related potentials (ERPs) represent valuable indices of neural timing mechanisms in the millisecond-to-second domain. We used an interference approach by repetitive TMS (rTMS) on ERPs and behavioral performance to investigate the role of different cortical areas in processing basic temporal information. Ten healthy volunteers were requested to decide whether time intervals between two tones (S1-S2, probe interval) were shorter (800 ms), equal to, or longer (1200 ms) than a previously listened 1000-ms interval (target interval) and press different buttons accordingly. This task was performed at the b…

AdultMalemedicine.medical_specialtymedicine.medical_treatmentPosterior parietal cortexPilot ProjectsElectroencephalographyAudiologyTranscranial Direct Current Stimulationbehavioral disciplines and activitiesDevelopmental psychologyTask (project management)Young AdultDiscrimination PsychologicalmedicineReaction TimeHumansPilot ProjectTimingContingent negative variationDiscrimination (Psychology)Cerebral CortexNeuroscience (all)Supplementary motor areamedicine.diagnostic_testSettore M-PSI/02 - Psicobiologia E Psicologia Fisiologicamusculoskeletal neural and ocular physiologyGeneral NeuroscienceMiddle AgedContingent negative variationTranscranial magnetic stimulationInterval (music)medicine.anatomical_structureDuration (music)Time PerceptionAuditory PerceptionEvoked Potentials AuditoryFemalePsychologypsychological phenomena and processesERPTranscranial magnetic stimulationHumanNeuroscience
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