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RESEARCH PRODUCT

"…The times they aren't a-changin'…" rTMS does not affect basic mechanisms of temporal discrimination: a pilot study with ERPs.

Gaetano ZaccaraFabio GiovannelliMaria Pia ViggianoE. Del SordoMassimo CincottaD. BattistaV. TarantinoA. RagazzoniTessa MarziG. Avanzini

subject

AdultMalemedicine.medical_specialtymedicine.medical_treatmentPosterior parietal cortexPilot ProjectsElectroencephalographyAudiologyTranscranial Direct Current Stimulationbehavioral disciplines and activitiesDevelopmental psychologyTask (project management)Young AdultDiscrimination PsychologicalmedicineReaction TimeHumansPilot ProjectTimingContingent negative variationDiscrimination (Psychology)Cerebral CortexNeuroscience (all)Supplementary motor areamedicine.diagnostic_testSettore M-PSI/02 - Psicobiologia E Psicologia Fisiologicamusculoskeletal neural and ocular physiologyGeneral NeuroscienceMiddle AgedContingent negative variationTranscranial magnetic stimulationInterval (music)medicine.anatomical_structureDuration (music)Time PerceptionAuditory PerceptionEvoked Potentials AuditoryFemalePsychologypsychological phenomena and processesERPTranscranial magnetic stimulationHuman

description

In time processing, the role of different cortical areas is still under investigation. Event-related potentials (ERPs) represent valuable indices of neural timing mechanisms in the millisecond-to-second domain. We used an interference approach by repetitive TMS (rTMS) on ERPs and behavioral performance to investigate the role of different cortical areas in processing basic temporal information. Ten healthy volunteers were requested to decide whether time intervals between two tones (S1-S2, probe interval) were shorter (800 ms), equal to, or longer (1200 ms) than a previously listened 1000-ms interval (target interval) and press different buttons accordingly. This task was performed at the baseline and immediately after a 15-min-long train of 1-Hz rTMS delivered over the supplementary motor area, right posterior parietal cortex, right superior temporal gyrus, or an occipital control area. Task accuracy, reaction time, and ERPs during (contingent negative variation, CNV) and after the presentation of probe intervals were analyzed. At the baseline, CNV amplitude was modulated by the duration of the probe interval. RTMS had no significant effect on behavioral or ERP measures. These preliminary data suggest that stimulated cortical areas are less crucially involved than other brain regions (e.g. subcortical structures) in the explicit discrimination of auditory time intervals in the range of hundreds of milliseconds.

yearjournalcountryeditionlanguage
2014-04-22Neuroscience
10.1016/j.neuroscience.2014.08.024https://pubmed.ncbi.nlm.nih.gov/25168726