0000000000757301
AUTHOR
Daniela Lötsch
Another step toward DNA selective targeting: NiII and CuII complexes of a Schiff base ligand able to bind gene promoter G-quadruplexes
DNA G-rich sequences are able to form four-stranded structures organized in stacked guanine tetrads. These structures, called G-quadruplexes, were found to have an important role in the regulation of oncogenes expression and became, for such a reason, appealing targets for anticancer drugs. Aiming at finding selective G-quadruplex binders, we have designed, synthesized and characterized a new water soluble Salen-like Schiff base ligand and its NiII and CuII metal complexes. UV-Vis, circular dichroism and FRET measurements indicated that the nickel complex can stabilize oncogene promoter G-quadruplexes with high selectivity, presenting no interactions with duplex DNA at all. The same compoun…
Self-assembled Pt2L2 boxes strongly bind G-quadruplex DNA and influence gene expression in cancer cells
Supramolecular Pt(ii) quadrangular boxes bind native and G-quadruplex DNA motifs in a size-dependent fashion. Three Pt molecular squares of distinct size show biological activity against cancer cells and heavily influence the expression of genes known to form G-quadruplexes in their promoter regions. The smallest Pt-box displays less activity but more selectivity for a quadruplex formed in the c-Kit gene.
CCDC 1451695: Experimental Crystal Structure Determination
Related Article: Alessio Terenzi, Daniela Lötsch, Sushilla van Schoonhoven, Alexander Roller, Christian R. Kowol, Walter Berger, Bernhard K. Keppler, Giampaolo Barone|2016|Dalton Trans.|45|7758|doi:10.1039/C6DT00648E
CCDC 1451694: Experimental Crystal Structure Determination
Related Article: Alessio Terenzi, Daniela Lötsch, Sushilla van Schoonhoven, Alexander Roller, Christian R. Kowol, Walter Berger, Bernhard K. Keppler, Giampaolo Barone|2016|Dalton Trans.|45|7758|doi:10.1039/C6DT00648E
CCDC 1451696: Experimental Crystal Structure Determination
Related Article: Alessio Terenzi, Daniela Lötsch, Sushilla van Schoonhoven, Alexander Roller, Christian R. Kowol, Walter Berger, Bernhard K. Keppler, Giampaolo Barone|2016|Dalton Trans.|45|7758|doi:10.1039/C6DT00648E