Self-assembled Pt2L2 boxes strongly bind G-quadruplex DNA and influence gene expression in cancer cells

6533b832fe1ef96bd129adfd

RESEARCH PRODUCT

Self-assembled Pt2L2 boxes strongly bind G-quadruplex DNA and influence gene expression in cancer cells

Carina Dinhof S Van Schoonhoven Olaya Domarco Marcos Garcia Carlos Peinador Alessio Terenzi Alessio Terenzi J. Schreiber Walter Berger Daniela Lötsch Bernhard K. Keppler Bernhard K. Keppler

subject

010405 organic chemistry Chemistry Supramolecular chemistry Biological activity 010402 general chemistry G-quadruplex 01 natural sciences Molecular biology 0104 chemical sciences Self assembled Cell biology Inorganic Chemistry chemistry.chemical_compound G-quadruplex Platinum Settore CHIM/03 - Chimica Generale E Inorganica Gene expression Cancer cell heterocyclic compounds Gene DNA

description

Supramolecular Pt(ii) quadrangular boxes bind native and G-quadruplex DNA motifs in a size-dependent fashion. Three Pt molecular squares of distinct size show biological activity against cancer cells and heavily influence the expression of genes known to form G-quadruplexes in their promoter regions. The smallest Pt-box displays less activity but more selectivity for a quadruplex formed in the c-Kit gene.

year	journal	country	edition	language
2017-01-01	Dalton Transactions

https://doi.org/10.1039/c6dt03876j

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