Effects of organotin(IV)(metal-sulfonatophenyl)porphinates on the growth of A375 human melanoma cells

Effect of environmental stress on sea urchin embryos and larvae: from developmental to molecular biology analyses

Skeleton growth inhibition in sea urchin embryos Paracentrotus lividus after manganese exposure.

In the sea urchin embryos, skeleton is specified by interactions between PMCs and patterning cues derived from the ectoderm. PMCs use spatial and temporal information to organize the proper animal-vegetal and oral-aboral position and orientation of the two tri-radiate skeletal spicules. Many experiments have demonstrated that exposure to metals, such as lithium, zinc and nickel, can disrupt skeleton patterning information. Here, we have investigated the effects of manganese (Mn) on Paracentrotus lividus embryo development. We found that Mn exposure prevents skeleton growth producing spicule-lacking embryos. Normal skeleton growth was partially rescued after Mn removal from the culture. To d…

Affinamento dei vini rossi sur lies

Porphyrin tributyltin(IV) complexes for a novel approach in the tratment of human melanoma

Melanoma is the most deadly form of skin cancer, largely refractory to existing therapies. The study of porphyrin derivatives as potential anti-tumor drugs has been an interesting field of investigation in the last years. Recently, a photo-independent cytotoxic effect of (Bu3Sn)4TPPS in the blocking melanoma cell proliferation an inducing a morphology cell change was investigated.[1] Amphiphilic CD (ACyD) provides more water soluble and adaptable nanovectors through modulation of the balance between hydrophobic and hydrophilic chains at both CD sides. ACyD can be conveniently tailored by covalently appending fluorescent label or receptor-targeting glycosyl- groups and can encapsulate conven…