0000000000758920
AUTHOR
I. Filippi
DIFFERENTIAL INFLUENCE OF HYPOXIA ON GENE EXPRESSION OF TUMORAL AND NON TUMORAL MAMMARY CELLS
Cancer metastasis is the result of a series of deregulated biological phenomena, including alterations of cell-cell and cell-matrix interactions and of other microenvironmental conditions such as the oxygen tissue supply. Hypoxia is a well-known driver of aggressive cancer phenotypes, indeed tumors with poor prognosis have higher proportions of anoxic and hypoxic areas1. The consequences of tumour hypoxia can be local or even systemic towards distant organs, and it can evoke diversified responses: whereas low oxygen concentration in tissue environments. (pO2 <7 mmHg) exerts anti-proliferative effects and promotes differentiation, apoptosis and/or necrosis on normal cells, the tumoral cells …
COMPARATIVE PROTEOMIC PROFILING OF NORMAL AND BREAST CANCER CELLS UNDER HYPOXIC CONDITIONS
influences emanating from the tissue microenvironment, such as cell-cell and cell-matrix interactions and other local pathophysiologic conditions as hypoxia. However the hypoxic effect may be different according to the cell conditions. For example, the low concentration of tissue oxygen (pO2 <7 mmHg) may exert anti-proliferative effects on normal cells and may induce differentiation or apoptosis and necrosis. On the other contrary, tumour cells likely react to hypoxic stress with an adaptive process through modification of gene expression that may confer an aggressive phenotype to cells, promoting their local and distant spread [1]. In general it is believed that hypoxic microenvironments i…