Serotonin-Dopamine interaction in Nicotine Addiction: Focus on 5-HT2C Receptors

Central dopaminergic systems play a critical role in the regulation of normal and abnormal behaviors. Recent evidence suggests that a dysfunction of dopamine (DA) and serotonin (5-HT) neurotransmitter systems contribute to various pathological conditions. Substantial evidence indicates that the mesolimbic pathway, particularly the DA cells innervating accumbal areas, is implicated in the reward value of both natural and drug reinforcers, such as sexual behavior or psychostimulants, respectively. Nicotine, the major psychoactive agent present in tobacco, acts as a potent addictive drug both in humans and laboratory animals. The locomotor activation and the reinforcing effects of nicotine may…