0000000000760419

AUTHOR

I. Just

showing 2 related works from this author

Influence of double infections on the induction of thymidine kinase by UV-irradiated herpes simplex virus types 1 and 2 and pseudorabies virus

1975

Simultaneous infection of primary rabbit kidney cells with HSV type 1 TK+ and a TK- strain results in a mutual influence of both viruses on the induction of thymidine kinase (TK). TK+ virus has an enhancing and TK- virus a depressing effect on TK induction by a superinfecting TK+ virus. The enzyme induction depends on the ratio of multiplicities of both viruses. The mutual influence on TK induction depends further on the time of addition of the superinfecting virus: the effect of the second virus can still be observed when given 6 hours after primary infection. Identical phenomena can be observed using combinations with HSV type 2 or Pseudorabies viruses. The ability of HSV to induce TK is …

Ultraviolet RaysvirusesPseudorabiesHSL and HSVBiologyVirus Replicationmedicine.disease_causeThymidine KinaseVirusCulture TechniquesVirologyViral InterferencemedicineRabbit kidneySimplexvirusCycloheximideEnzyme inducerHerpesviridaeCell-Free SystemStrain (chemistry)CytarabineGeneral Medicinebiology.organism_classificationHerpesvirus 1 SuidVirologyMolecular biologyRadiation EffectsHerpes simplex virusThymidine kinaseEnzyme InductionMutationbiology.proteinArchives of Virology
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Inhibition of giant cell formation by compound 48/80 after infection with herpesvirus hominis

1974

Choline kinase has been found to be a soluble enzyme with a molecular weight of 105,000 in the cytoplasm of primary rabbit kidney cells. It has been purified 150-fold. It was investigated whether the inhibiting effect of Cpd 48/80 on virus-induced giant cell formation is due to interference with this enzyme. Cpd 48/80-dimer was shown to inhibit the choline kinase activityin vitro without a concomitant inhibition of giant cell formation. Likewise, another competitive inhibitor of choline kinase, purinyl-6-histamine, does not prevent giant cell formation. This finding suggests that there is no correlation between choline kinase activity and giant cell formation.

Time FactorsCholine kinaseeducationGalactosamineOleic AcidsBiologyKidneyTritiumCholinechemistry.chemical_compoundCytopathogenic Effect ViralBiosynthesisVirologyAnimalsSimplexvirusp-Methoxy-N-methylphenethylamineCarbon RadioisotopesCells Culturedchemistry.chemical_classificationGlucosamineBinding SitesPhosphotransferasesGeneral MedicineCompound 48/80LipidsVirologyMolecular biologyIn vitroEnzymechemistryEthanolaminesCytoplasmGiant cellDepression ChemicalPhosphatidylcholinesTritiumChromatography Thin LayerRabbitsArchiv f�r die gesamte Virusforschung
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