Psychobiological effects of perinatal exposure to odorants in mice. Part II: Behavioural alteration

Early exposure to odorants pre-, post- or transnatally is known to. result in a decreased avoidance or increased preference for these. odorants in mammals. There are also indications that olfactory sensitivity. for these odorants can be affected. We exposed C57-Bl/6. mice of Mor23-GFP and M71-GFP lines to lyral (LY) or acetophenone. (AC), respectively, either transnatally through the water of the. mother (1*10-5 M) or postnatally in air for 1 hr per day (20 ll pure). Animals were weaned on postnatal day 20 (P20), and 3 tests were. performed:. 1) A 3-min exploration test on P20 in a rectangular arena presenting. LY and AC under a wire mesh to measure the time spent in each. half of the arena…