0000000000764713

AUTHOR

Thomas Keller

showing 4 related works from this author

Measurement of exhaled nitric oxide: comparison of 3 different analyzers

2018

Exhaled nitric oxide (FeNO) is used as a surrogate marker to monitor airway inflammation. Aim of this study was to compare the new FeNO analyzer Vivatmo pro from Bosch (BV) with the Niox Vero from Circassia (CN) and the CLD from Ecomedics (EC). In 106 asthma patients (median age 54 years (range 20-87), 60 % female, median ACT of 16, 85 % on inhaled corticosteroids (mean 1300 μg BDP), 36 % on therapy with biologics) 2 FeNO measurements per patient and per device were performed using each analyzer in a random sequence according to the ATS / ERS guidelines. Additionally, the success rate to achieve a valid NO value was evaluated. 70 % of the patients had FeNO values In conclusion, for the rang…

medicine.medical_specialtySurrogate endpointbusiness.industryAirway inflammationInhaled corticosteroidsrespiratory systemmedicine.diseaseGastroenterologyrespiratory tract diseasesInternal medicineExhaled nitric oxidemedicinebusinessAsthmaMonitoring Airway Disease
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Measurement of Fractional Exhaled Nitric Oxide: Comparison of Three Different Analysers

2019

<b><i>Background:</i></b> Fractional exhaled nitric oxide (FeNO) is a surrogate marker for airway inflammation, supporting the diagnostic pathway and treatment decisions for asthma patients. <b><i>Objectives:</i></b> Aim of this study was to compare the new analyser Vivatmo pro (Bosch, BV) with NIOX VERO (Circassia, CN) and CLD (Ecomedics, EC). <b><i>Methods:</i></b> In 100 asthmatics (median 53 years [range 20–87], 62% female, 86% on inhaled corticosteroids [mean 1,300 μg beclomethasone dipropionate or equivalent], 35% treated with biologics) 2 FeNO measurements per device were performed. Additionally, the success rate…

AdultMalePulmonary and Respiratory Medicinemedicine.medical_specialtyVital CapacityAnalyserClinical InvestigationsUrologyInhaled corticosteroidsNitric OxideYoung Adult03 medical and health sciences0302 clinical medicineForced Expiratory VolumeHumansMedicineAnti-Asthmatic Agents030212 general & internal medicineAgedAsthmaAged 80 and overbusiness.industryAirway inflammationMiddle Agedrespiratory systemmedicine.diseaseAsthmarespiratory tract diseasesBreath Tests030228 respiratory systemExhaled nitric oxideFemaleTreatment decision makingbusinessRespiration
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Determination of ethyl sulfate – a marker for recent ethanol consumption – in human urine by CE with indirect UV detection

2006

A CE method for the determination of the ethanol consumption marker ethyl sulfate (EtS) in human urine was developed. Analysis was performed in negative polarity mode with a background electrolyte composed of 15 mM maleic acid, 1 mM phthalic acid, and 0.05 mM cetyltrimethylammonium bromide (CTAB) at pH 2.5 and indirect UV detection at 220 nm (300 nm reference wavelength). This buffer system provided selective separation conditions for EtS and vinylsulfonic acid, employed as internal standard, from urine matrix components. Sample pretreatment of urine was minimized to a 1:5 dilution with water. The optimized CE method was validated in the range of 5-700 mg/L using seven lots of urine. Intra-…

AdultMaleBioanalysisAlcohol DrinkingMaleic acidClinical BiochemistryPhthalic AcidsUrineBuffersSulfuric Acid EstersBiochemistryEthyl sulfateVinylsulfonic acidAnalytical ChemistryMatrix (chemical analysis)Forensic Toxicologychemistry.chemical_compoundHumansChromatographyEthanolCetrimoniumMaleatesElectrophoresis CapillaryDilutionPhthalic acidchemistryCetrimonium CompoundsFemaleSpectrophotometry UltravioletBiomarkersChromatography LiquidELECTROPHORESIS
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Membre du comité d'organisation scientifique

2020

comité d'organisation scientifique; International audience

[SDE] Environmental Sciences[SDE]Environmental SciencesComputingMilieux_MISCELLANEOUS
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