6533b830fe1ef96bd1297a09
RESEARCH PRODUCT
Measurement of exhaled nitric oxide: comparison of 3 different analyzers
Thomas KellerRoland BuhlStephanie KornStefanie VoigtMaike Wilksubject
medicine.medical_specialtySurrogate endpointbusiness.industryAirway inflammationInhaled corticosteroidsrespiratory systemmedicine.diseaseGastroenterologyrespiratory tract diseasesInternal medicineExhaled nitric oxidemedicinebusinessAsthmadescription
Exhaled nitric oxide (FeNO) is used as a surrogate marker to monitor airway inflammation. Aim of this study was to compare the new FeNO analyzer Vivatmo pro from Bosch (BV) with the Niox Vero from Circassia (CN) and the CLD from Ecomedics (EC). In 106 asthma patients (median age 54 years (range 20-87), 60 % female, median ACT of 16, 85 % on inhaled corticosteroids (mean 1300 μg BDP), 36 % on therapy with biologics) 2 FeNO measurements per patient and per device were performed using each analyzer in a random sequence according to the ATS / ERS guidelines. Additionally, the success rate to achieve a valid NO value was evaluated. 70 % of the patients had FeNO values In conclusion, for the range between 0-70 ppb, the exhaled NO concentrations measured with all 3 devices were found to be statistically equivalent within predefined acceptance criteria.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2018-09-15 | Monitoring Airway Disease |