0000000000765142
AUTHOR
Xin Wang
A multidimensional network approach reveals microRNAs as determinants of the mesenchymal colorectal cancer subtype
Colorectal cancer (CRC) is a heterogeneous disease posing a challenge for accurate classification and treatment of this malignancy. There is no common genetic molecular feature that would allow for the identification of patients at risk for developing recurrences and thus selecting patients who would benefit from more stringent therapies still poses a major clinical challenge. Recently, an international multicenter consortium (CRC Subtyping Consortium) was established aiming at the classification of CRC patients in biologically homogeneous CRC subtypes. Four consensus molecular subtypes (CMSs) were identified, of which the mesenchymal CMS4 presented with worse prognosis signifying the impor…
Effect of hydrogen bonds on polarizability of a water molecule in (H2O)(N) (N = 6, 10, 20) isomers.
Abstract: Polarizabilities of the low-lying isomers of (H2O)N (N = 6, 10, 20) clusters were computed by using Density Functional Theory. The global polarizabilities of the water isomers were found to depend mainly on the total number of water molecules rather than their cluster structures. We show that this result hides in fact a strong heterogeneity of the molecular polarizability within the different isomers. The global polarizability of a cluster was divided into a sum of molecular contributions by using the Hirshfeld partitioning scheme. We reveal that the value of the local polarizability of a molecule in the cluster is correlated with the number and type of the hydrogen bonds (HB) the…
Safflower Yellow and Its Main Component HSYA Alleviate Diet-Induced Obesity in Mice: Possible Involvement of the Increased Antioxidant Enzymes in Liver and Adipose Tissue
PurposeOxidative stress plays an important role in the pathogenesis of obesity and its associated disorders. Safflower yellow (SY) and hydroxysafflor yellow A (HSYA), the natural compounds isolated from Carthamus tinctorius L., has been found to possess antioxidative and anti-obesity properties. The purpose of the present study is to investigate whether SY and its main component HSYA alleviate obesity by the antioxidant effects.MethodsDiet-induced obese (DIO) mice were treated with 200 mg/kg/d SY or HSYA for 10 weeks. Body weight, fat mass, serum biochemical parameters and superoxide dismutase (SOD) activities were measured. Glucose and insulin tolerance tests were performed. The expression…
Monitoring Water and Energy Cycles at Climate Scale in the Third Pole Environment (CLIMATE-TPE)
A better understanding of the water and energy cycles at climate scale in the Third Pole Environment is essential for assessing and understanding the causes of changes in the cryosphere and hydrosphere in relation to changes of plateau atmosphere in the Asian monsoon system and for predicting the possible changes in water resources in South and East Asia. This paper reports the following results: (1) A platform of in situ observation stations is briefly described for quantifying the interactions in hydrosphere-pedosphere-atmosphere-cryosphere-biosphere over the Tibetan Plateau. (2) A multiyear in situ L-Band microwave radiometry of land surface processes is used to develop a new microwave r…
Early Results from GLASS-JWST. XX. Unveiling a Population of “Red Excess” Galaxies in Abell2744 and in the Coeval Field
We combine JWST/NIRCam imaging and MUSE data to characterize the properties of galaxies in different environmental conditions in the cluster Abell2744 ($z=0.3064$) and in its immediate surroundings. We investigate how galaxy colors, morphology and star forming fractions depend on wavelength and on different parameterizations of environment. Our most striking result is the discovery of a ``red-excess'' population in F200W$-$F444W colors both in the cluster regions and the field. These galaxies have normal F115W$-$F150W colors, but are up to 0.8 mag redder than red sequence galaxies in F200W$-$F444W. They also have rather blue rest frame B$-$V colors. {Galaxies in the field and at the cluster…
The GLASS-JWST Early Release Science Program. III. Strong lensing model of Abell 2744 and its infalling regions
We present a new high-precision, JWST-based, strong lensing model for the galaxy cluster Abell 2744 at $z=0.3072$. By combining the deep, high-resolution JWST imaging from the GLASS-JWST and UNCOVER programs and a Director's Discretionary Time program, with newly obtained VLT/MUSE data, we identify 32 multiple images from 11 background sources lensed by two external sub-clusters at distances of ~160" from the main cluster. The new MUSE observations enable the first spectroscopic confirmation of a multiple image system in the external clumps. Moreover, the re-analysis of the spectro-photometric archival and JWST data yields 27 additional multiple images in the main cluster. The new lens mode…
Consensus molecular subtypes of colorectal cancer are recapitulated in in vitro and in vivo models
Colorectal cancer (CRC) is a highly heterogeneous disease both from a molecular and clinical perspective. Several distinct molecular entities, such as microsatellite instability (MSI), have been defined that make up biologically distinct subgroups with their own clinical course. Recent data indicated that CRC can be best segregated into four groups called consensus molecular subtypes (CMS1-4), each of which has a unique biology and gene expression pattern. In order to develop improved, subtype-specific therapies and to gain insight into the molecular wiring and origin of these subtypes, reliable models are needed. This study was designed to determine the heterogeneity and identify the prese…
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
Seuls les 100 premiers auteurs dont les auteurs INRA ont été entrés dans la notice. La liste complète des auteurs et de leurs affiliations est accessible sur la publication.; International audience; In 2008 we published the first set of guidelines for standardizing research in autophagy. Since then, research on this topic has continued to accelerate, and many new scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Accordingly, it is important to update these guidelines for monitoring autophagy in different organisms. Various reviews have described the range of assays that have been used for this purpose. Nevertheless, there continues…
A measurement-based study on the correlations of inter-domain Internet application flows
Internet traffic characterization has a profound impact on network engineering and traffic identification. Existing studies are often carried out on a per-flow basis, focusing on the properties of individual flows. In this paper, we study the interaction of Internet traffic flows and network features from a complex network perspective, focusing on six types of applications: P2P file sharing, P2P stream, HTTP, instant messaging, online games and abnormal traffic. With large-volume traffic flow records collected through proprietary line-speed hardware-based monitors, we construct flow graphs of these different application types. Based on the flow graphs, we calculate the correlation coefficie…
A large cross-ancestry meta-analysis of genome-wide association studies identifies 69 novel risk loci for primary open-angle glaucoma and includes a genetic link with Alzheimer’s disease
AbstractWe conducted a large multi-ethnic meta-analysis of genome-wide association studies for primary open-angle glaucoma (POAG) on a total of 34,179 cases vs 349,321 controls, and identified 127 independent risk loci, almost doubling the number of known loci for POAG. The majority of loci have broadly consistent effect across European, Asian and African ancestries. We identify a link, both genome-wide and at specific loci, between POAG and Alzheimer’s disease. Gene expression data and bioinformatic functional analyses provide further support for the functional relevance of the POAG risk genes. Several drug compounds target these risk genes and may be potential candidates for developing no…
Erratum
Author(s): Klionsky, DJ; Abdelmohsen, K; Abe, A; Abedin, MJ; Abeliovich, H; Arozena, AA; Adachi, H; Adams, CM; Adams, PD; Adeli, K; Adhihetty, PJ; Adler, SG; Agam, G; Agarwal, R; Aghi, MK; Agnello, M; Agostinis, P; Aguilar, PV; Aguirre-Ghiso, J; Airoldi, EM; Ait-Si-Ali, S; Akematsu, T; Akporiaye, ET; Al-Rubeai, M; Albaiceta, GM; Albanese, C; Albani, D; Albert, ML; Aldudo, J; Algul, H; Alirezaei, M; Alloza, I; Almasan, A; Almonte-Beceril, M; Alnemri, ES; Alonso, C; Altan-Bonnet, N; Altieri, DC; Alvarez, S; Alvarez-Erviti, L; Alves, S; Amadoro, G; Amano, A; Amantini, C; Ambrosio, S; Amelio, I; Amer, AO; Amessou, M; Amon, A; An, Z; Anania, FA; Andersen, SU; Andley, UP; Andreadi, CK; Andrieu-Ab…